PDF(Pubmed)
Abstract：
Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. HAP1 has diverse functions involving in vesicular transport, receptor recycling, gene transcription, and signal transduction. HAP1 is strongly linked to several neurological diseases, including Huntington\'s disease, Alzheimer\'s disease, epilepsy, ischemic stroke, and depression. In addition, HAP1 has been proved to participate in cancers and diabetes mellitus. This article provides an overview of HAP1 regarding the tissue distribution, cell localization, functions, and offers fresh perspectives to investigate its role in diseases.
摘要：
亨廷顿蛋白相关蛋白1（HAP1）是第一个与亨廷顿蛋白相互作用的蛋白质。除了大脑,HAP1也在脊髓中表达，背根神经节，内分泌，和消化系统。HAP1具有涉及囊泡运输的多种功能，受体再循环，基因转录，和信号转导。HAP1与几种神经系统疾病密切相关，包括亨廷顿病,老年痴呆症,癫痫,缺血性卒中,和抑郁症。此外,HAP1已被证明参与癌症和糖尿病。本文概述了HAP1的组织分布，细胞定位，功能,并提供了新的观点来研究其在疾病中的作用。
