Indolent CD8-positive T-LPD of the peripheral nervous system in a 19-year-old man.

19 岁男性外周神经系统的惰性 CD8 阳性 T - LPD 。

• 影响指数: 3.776
• 发表时间: 2024 Jun 30
• 来源期刊: Heliyon
• DOI: 10.1016/j.heliyon.2024.e32173
• PMID: 38975162
• 文章类型: Case Reports
• 作者列表: Zhu X,Zhang B,Jin X,Zhou L,Cao L,Yu H,Luan X

关键词: CD8; Chronic inflammatory demyelinating polyneuropathy; Neurolymphomatosis; Peripheral neuropathy; T-cell lymphoproliferative disorder

Abstract

A 19-year-old man presented with recurrent intermittent fever, progressive limbs weakness, numbness, and atrophy for 5 years. Biopsy of the sural nerve, spleen, lymph nodes, bone marrow and labial gland revealed that monomorphic small lymphoid cells infiltrated diffusely and that there was severe loss of large myelinated nerve fibers. Immunohistochemically, these cells were mainly CD8-positive T cells and were positive for CD3 and CD57. This patient was diagnosed as indolent CD8-positive T lymphoproliferative disorder (indolent CD8-positive T-LPD), emphasizing the need for a broad differential diagnosis under these conditions, and nerve biopsy should be performed.

摘要

一名19岁男子反复出现间歇性发烧，进行性四肢无力,麻木,萎缩了5年.腓肠神经活检,脾,脾淋巴结,骨髓和唇腺显示单形小淋巴细胞弥漫性浸润，并且有大量有髓神经纤维严重丧失。免疫组织化学，这些细胞主要是CD8阳性T细胞，对CD3和CD57呈阳性。该患者被诊断为惰性CD8阳性T淋巴细胞增生性疾病（惰性CD8阳性T-LPD），强调在这些条件下需要广泛的鉴别诊断，并进行神经活检。