PDF(Pubmed)
Abstract：
Neurosyphilis is a central nervous system infection caused by Treponema pallidum that imitates various neurological and mental disorders. Therefore, patients with this disease are prone to misdiagnoses. Here, we report a case of neurosyphilis with a psychotic disorder as the main manifestation. A young girl exhibited mental and behavioural abnormalities after a heartbreak, which manifested as alternating low mood, emotional irritability, and a lack of interest in social relations, followed by memory loss. The cerebrospinal fluid protein - Treponema pallidum particle agglutination test was positive, the toluidine red unheated serum test titre was 1:4, the white blood cell count was 5 × 10^6/L, the cerebrospinal fluid protein level was 0.97 g/L, and the brain CT was abnormal. After admission, the possibility of neurosyphilis was considered and the patient received intravenous penicillin G treatment. The patient\'s clinical symptom ms improved. This case emphasises that doctors should maintain clinical suspicion of Treponema pallidum infection in adolescent patients with mental abnormalities.
摘要：
神经梅毒是由梅毒螺旋体引起的中枢神经系统感染，模仿各种神经和精神障碍。因此,患有这种疾病的患者容易误诊。这里,我们报告一例以精神病性障碍为主要表现的神经梅毒。一个年轻女孩在心碎后表现出精神和行为异常，表现为交替低落的情绪，情绪烦躁，对社会关系缺乏兴趣，其次是记忆丧失。脑脊液蛋白-梅毒螺旋体颗粒凝集试验阳性，甲苯胺红未加热血清试验滴度为1:4，白细胞计数为5×10^6/L，脑脊液蛋白水平为0.97g/L,脑部CT异常.入院后,考虑了神经梅毒的可能性,患者接受了青霉素G静脉注射治疗.患者的临床症状改善。该病例强调，医生应在临床上怀疑患有精神异常的青少年患者的梅毒螺旋体感染。
