PDF(Pubmed)
Abstract：
Lung hyperinflation (LH) is a common clinical feature in patients with chronic obstructive pulmonary disease (COPD). It results from a combination of reduced elastic lung recoil as a consequence of irreversible destruction of lung parenchyma and expiratory airflow limitation. LH is an important determinant of morbidity and mortality in COPD, partially independent of the degree of airflow limitation. Therefore, reducing LH has become a major target in the treatment of COPD over the last decades. Advances were made in the diagnostics of LH and several effective interventions became available. Moreover, there is increasing evidence suggesting that LH is not only an isolated feature in COPD but rather part of a distinct clinical phenotype that may require a more integrated management. This narrative review focuses on the pathophysiology and adverse consequences of LH, the assessment of LH with lung function measurements and imaging techniques and highlights LH as a treatable trait in COPD. Finally, several suggestions regarding future studies in this field are made.
摘要：
肺过度充气（LH）是慢性阻塞性肺疾病（COPD）患者的常见临床特征。它是由于肺实质的不可逆破坏和呼气气流受限而导致的弹性肺反冲减少的组合。LH是COPD发病率和死亡率的重要决定因素，部分独立于气流限制的程度。因此,在过去的几十年中,降低LH已成为COPD治疗的主要目标.在LH的诊断方面取得了进展，并且有几种有效的干预措施。此外，越来越多的证据表明,LH不仅是COPD患者的一个孤立特征,而且是一种独特临床表型的一部分,可能需要更综合的治疗.这篇叙述性综述侧重于LH的病理生理学和不良后果，通过肺功能测量和成像技术评估LH，并强调LH是COPD的可治疗特征。最后,对该领域未来的研究提出了一些建议。
