PDF(Pubmed)
Abstract：
UNASSIGNED: Modern-day obstetrics recommend induction of labor by medical or mechanical methods where continuation of pregnancy causes detrimental effect to the health of mother or fetus. One of the prerequisites for successful vaginal delivery includes a favorable or ripe cervix. We undertook the present study to find out the safety and efficacy of mifepristone for pre-induction cervical ripening and its effect on Bishop\'s score in term pregnancy.
UNASSIGNED: A total of 100 patients with term pregnancy were enrolled for this study. 200 mg of mifepristone was administered orally, and efficacy of mifepristone was assessed based on improvement in modified Bishop\'s score at 48 h. If there was inadequate improvement in Bishop\'s score after 48 h, additional intracervical cerviprime was administered for induction.
UNASSIGNED: Out of 100 patients, 50 women delivered vaginally after administration of mifepristone. Twenty-four patients delivered vaginally within 48 h of administration of mifepristone. We observed the Bishop\'s score of 6 or more at 48 h in 69% participants. Fifty patients required additional intracervical cerviprime. Thirty participants underwent cesarean section. Mean Modified Bishop\'s score at 0 h was 1.87 and improved to 6.92 after 48 h after mifepristone. A statistically significant difference was found with mean Bishop\'s score with p value < 0.005.
UNASSIGNED: In our study, we found that mifepristone is a safe and effective cervical ripening agent in term pregnancy with unfavorable cervix. It is well tolerated and leads to significant cervical ripening with improvement in Bishop\'s score favoring vaginal delivery.
UNASSIGNED: A total of 100 patients with term pregnancy were enrolled for this study. 200 mg of mifepristone was administered orally, and efficacy of mifepristone was assessed based on improvement in modified Bishop\'s score at 48 h. If there was inadequate improvement in Bishop\'s score after 48 h, additional intracervical cerviprime was administered for induction.
UNASSIGNED: Out of 100 patients, 50 women delivered vaginally after administration of mifepristone. Twenty-four patients delivered vaginally within 48 h of administration of mifepristone. We observed the Bishop\'s score of 6 or more at 48 h in 69% participants. Fifty patients required additional intracervical cerviprime. Thirty participants underwent cesarean section. Mean Modified Bishop\'s score at 0 h was 1.87 and improved to 6.92 after 48 h after mifepristone. A statistically significant difference was found with mean Bishop\'s score with p value < 0.005.
UNASSIGNED: In our study, we found that mifepristone is a safe and effective cervical ripening agent in term pregnancy with unfavorable cervix. It is well tolerated and leads to significant cervical ripening with improvement in Bishop\'s score favoring vaginal delivery.
摘要：
■现代产科建议通过医学或机械方法引产，如果继续妊娠会对母亲或胎儿的健康产生不利影响。成功阴道分娩的先决条件之一包括有利的或成熟的子宫颈。我们进行了本研究，以了解米非司酮用于诱导宫颈成熟前的安全性和有效性及其对足月妊娠Bishop评分的影响。
■本研究共纳入100例足月妊娠患者。口服200毫克米非司酮，根据48h时Bishop评分的改善情况评估米非司酮的疗效。如果48h后Bishop评分改善不足，额外的宫颈内给药用于诱导。
■在100名患者中，50名妇女在服用米非司酮后阴道分娩。24例患者在服用米非司酮后48小时内阴道分娩。我们观察到69%的参与者在48小时Bishop’s得分为6分或以上。50名患者需要额外的子宫颈素。30名参与者接受了剖宫产。米非司酮后0h的平均改良Bishop评分为1.87，48h后改善为6.92。在P值<0.005的平均Bishop评分下发现统计学上的显著差异。
■在我们的研究中，我们发现米非司酮是一种安全有效的宫颈成熟剂，用于足月妊娠宫颈不良。它具有良好的耐受性，并导致宫颈明显成熟，Bishop评分改善有利于阴道分娩。
■本研究共纳入100例足月妊娠患者。口服200毫克米非司酮，根据48h时Bishop评分的改善情况评估米非司酮的疗效。如果48h后Bishop评分改善不足，额外的宫颈内给药用于诱导。
■在100名患者中，50名妇女在服用米非司酮后阴道分娩。24例患者在服用米非司酮后48小时内阴道分娩。我们观察到69%的参与者在48小时Bishop’s得分为6分或以上。50名患者需要额外的子宫颈素。30名参与者接受了剖宫产。米非司酮后0h的平均改良Bishop评分为1.87，48h后改善为6.92。在P值<0.005的平均Bishop评分下发现统计学上的显著差异。
■在我们的研究中，我们发现米非司酮是一种安全有效的宫颈成熟剂，用于足月妊娠宫颈不良。它具有良好的耐受性，并导致宫颈明显成熟，Bishop评分改善有利于阴道分娩。
