PDF(Pubmed)
Abstract：
UNASSIGNED: Atopic dermatitis is characterized by chronic inflammation and dryness accompanied by severe itching. The combined use of moisturizers and topical anti-inflammatory drugs is essential for alleviating atopic dermatitis. We have developed a topical anti-inflammatory drug with a steroid and a moisturizer with heparinoid, both in lamellar structure-based formulations containing synthetic pseudo-ceramides. Here, assessed the efficacy of this combination in the treatment of atopic dermatitis.
UNASSIGNED: We included 22 patients with mild to moderate atopic dermatitis and subjected them to a seven-week treatment with the test formulations, followed by a four-week post-treatment period.
UNASSIGNED: Clinical findings and the quality of life of participants remarkably improved after one week of treatment. Furthermore, skin hydration and transepidermal water loss considerably improved at weeks one and three, respectively. The Cer [NP]/[NS] ratio, an indicator of epidermal turnover, substantially increased during the treatment period and remained elevated even thereafter. The improvement in stratum corneum function was distinctive in participants with lower barrier function.
UNASSIGNED: These findings indicated that the combined use of the anti-inflammatory drug and moisturizer, both in lamellar structure-based formulations, is effective in treating atopic dermatitis in patients with fragile barrier function.
UNASSIGNED: We included 22 patients with mild to moderate atopic dermatitis and subjected them to a seven-week treatment with the test formulations, followed by a four-week post-treatment period.
UNASSIGNED: Clinical findings and the quality of life of participants remarkably improved after one week of treatment. Furthermore, skin hydration and transepidermal water loss considerably improved at weeks one and three, respectively. The Cer [NP]/[NS] ratio, an indicator of epidermal turnover, substantially increased during the treatment period and remained elevated even thereafter. The improvement in stratum corneum function was distinctive in participants with lower barrier function.
UNASSIGNED: These findings indicated that the combined use of the anti-inflammatory drug and moisturizer, both in lamellar structure-based formulations, is effective in treating atopic dermatitis in patients with fragile barrier function.
摘要：
■特应性皮炎的特征是慢性炎症和干燥伴有严重瘙痒。保湿剂和局部抗炎药的联合使用对于缓解特应性皮炎至关重要。我们已经开发了一种含有类固醇的局部抗炎药和含有类肝素的保湿剂，两者都在含有合成假神经酰胺的基于层状结构的制剂中。这里,评估了该组合治疗特应性皮炎的疗效。
■我们纳入了22名轻度至中度特应性皮炎患者，并对他们进行了为期7周的测试制剂治疗，随后是四周的治疗期。
■治疗一周后，患者的临床发现和生活质量显著改善。此外，在第1周和第3周时，皮肤水合作用和经表皮水分流失显着改善，分别。Cer[NP]/[NS]比率，表皮周转的指标,在治疗期间大幅增加，此后仍保持升高。角质层功能的改善在屏障功能较低的参与者中是独特的。
■这些研究结果表明，抗炎药和保湿剂的联合使用，都是基于层状结构的配方，对屏障功能脆弱的特应性皮炎患者有效。
■我们纳入了22名轻度至中度特应性皮炎患者，并对他们进行了为期7周的测试制剂治疗，随后是四周的治疗期。
■治疗一周后，患者的临床发现和生活质量显著改善。此外，在第1周和第3周时，皮肤水合作用和经表皮水分流失显着改善，分别。Cer[NP]/[NS]比率，表皮周转的指标,在治疗期间大幅增加，此后仍保持升高。角质层功能的改善在屏障功能较低的参与者中是独特的。
■这些研究结果表明，抗炎药和保湿剂的联合使用，都是基于层状结构的配方，对屏障功能脆弱的特应性皮炎患者有效。
