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Abstract：
UNASSIGNED: Cigarette smoking and low peripheral nitric oxide synthase (NOS) levels are strongly associated with sleep disorders. However, whether cerebrospinal fluid (CSF) NOS relates to sleep disorders and whether CSF NOS mediates the relationship between cigarette smoking and sleep disorders is unclear.
UNASSIGNED: We measured CSF levels of total NOS (tNOS) and its isoforms (inducible NOS [iNOS] and constitutive NOS [cNOS]) in 191 Chinese male subjects. We applied the Pittsburgh Sleep Quality Index (PSQI).
UNASSIGNED: The PSQI scores of active smokers were significantly higher than those of non-smokers, while CSF tNOS, iNOS, and cNOS were significantly lower (all p < 0.001). CSF tNOS, iNOS, and cNOS were negatively associated with PSQI scores in the general population (all p < 0.001). Mediation analysis suggested that CSF tNOS, iNOS, and cNOS mediate the relationship between smoking and PSQI scores, and the indirect effect accounted for 78.93%, 66.29%, and 81.65% of the total effect, respectively.
UNASSIGNED: Cigarette smoking is associated with sleep disorders. Active smokers had significantly lower CSF levels of tNOS, iNOS, and cNOS. Furthermore, tNOS, iNOS, and cNOS mediate the relationship between cigarette smoking and sleep quality. This study provides insights into how cigarette smoke affects sleep disorders.
UNASSIGNED: We measured CSF levels of total NOS (tNOS) and its isoforms (inducible NOS [iNOS] and constitutive NOS [cNOS]) in 191 Chinese male subjects. We applied the Pittsburgh Sleep Quality Index (PSQI).
UNASSIGNED: The PSQI scores of active smokers were significantly higher than those of non-smokers, while CSF tNOS, iNOS, and cNOS were significantly lower (all p < 0.001). CSF tNOS, iNOS, and cNOS were negatively associated with PSQI scores in the general population (all p < 0.001). Mediation analysis suggested that CSF tNOS, iNOS, and cNOS mediate the relationship between smoking and PSQI scores, and the indirect effect accounted for 78.93%, 66.29%, and 81.65% of the total effect, respectively.
UNASSIGNED: Cigarette smoking is associated with sleep disorders. Active smokers had significantly lower CSF levels of tNOS, iNOS, and cNOS. Furthermore, tNOS, iNOS, and cNOS mediate the relationship between cigarette smoking and sleep quality. This study provides insights into how cigarette smoke affects sleep disorders.
摘要：
■吸烟和外周一氧化氮合酶（NOS）水平低与睡眠障碍密切相关。然而,脑脊液（CSF）NOS是否与睡眠障碍有关，以及CSFNOS是否介导吸烟与睡眠障碍之间的关系尚不清楚。
■我们在191名中国男性受试者中测量了总NOS（tNOS）及其同工型（诱导型NOS[iNOS]和组成型NOS[cNOS]）的CSF水平。我们应用匹兹堡睡眠质量指数（PSQI）。
■活跃吸烟者的PSQI得分明显高于不吸烟者,而CSFtNOS，iNOS,和cNOS显著降低(均p<0.001)。CSFtNOS,iNOS,在一般人群中,cNOS与PSQI评分呈负相关(均p<0.001)。中介分析表明CSFtNOS，iNOS,cNOS介导吸烟与PSQI评分之间的关系，间接效应占78.93%，66.29%，和总效果的81.65%，分别。
■吸烟与睡眠障碍有关。活跃吸烟者的脑脊液tNOS水平明显降低，iNOS,和cNOS。此外，tNOS,iNOS,cNOS介导吸烟与睡眠质量的关系。这项研究提供了有关香烟烟雾如何影响睡眠障碍的见解。
■我们在191名中国男性受试者中测量了总NOS（tNOS）及其同工型（诱导型NOS[iNOS]和组成型NOS[cNOS]）的CSF水平。我们应用匹兹堡睡眠质量指数（PSQI）。
■活跃吸烟者的PSQI得分明显高于不吸烟者,而CSFtNOS，iNOS,和cNOS显著降低(均p<0.001)。CSFtNOS,iNOS,在一般人群中,cNOS与PSQI评分呈负相关(均p<0.001)。中介分析表明CSFtNOS，iNOS,cNOS介导吸烟与PSQI评分之间的关系，间接效应占78.93%，66.29%，和总效果的81.65%，分别。
■吸烟与睡眠障碍有关。活跃吸烟者的脑脊液tNOS水平明显降低，iNOS,和cNOS。此外，tNOS,iNOS,cNOS介导吸烟与睡眠质量的关系。这项研究提供了有关香烟烟雾如何影响睡眠障碍的见解。
