PDF(Pubmed)
Abstract：
UNASSIGNED: The treatment of multidrug-resistant tuberculosis (MDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) remains challenging due to the limited availability of effective drugs. Linezolid has emerged as a promising therapeutic option for these cases. However, its long-term use can lead to complications such as peripheral and optic neuropathies. Acupuncture, a cornerstone of traditional Chinese medicine, has been shown to be effective in the treatment of peripheral neuropathy (PN). This study examines the potential benefits of acupuncture in the treatment of linezolid-induced peripheral neuropathy (LIPN).
UNASSIGNED: Four patients, aged 27 to 60 years, diagnosed with LIPN, underwent daily acupuncture treatments. The main endpoint was to assess the efficacy of acupuncture in reducing neuropathic pain associated with LIPN in patients. This was primarily measured using changes in the Short Form McGill Pain Questionnaire (SF-MPQ) scores before and after acupuncture treatment.
UNASSIGNED: Three of the patients experienced significant symptom remission, while one experienced marginal improvement. Treatments ranged from 7 to 18 sessions. Specifically, the first patient reported substantial relief with a score reduction from 33 to 13; the second patient observed minimal change; the third patient\'s score decreased dramatically from 10 to 2 after eight sessions; the last patient had a score reduction from 21 to 12 after five sessions, but did not continue treatment for a second assessment.
UNASSIGNED: Acupuncture is a promising therapeutic approach for LIPN. However, larger and more thorough studies are needed to determine its full potential.
UNASSIGNED: Four patients, aged 27 to 60 years, diagnosed with LIPN, underwent daily acupuncture treatments. The main endpoint was to assess the efficacy of acupuncture in reducing neuropathic pain associated with LIPN in patients. This was primarily measured using changes in the Short Form McGill Pain Questionnaire (SF-MPQ) scores before and after acupuncture treatment.
UNASSIGNED: Three of the patients experienced significant symptom remission, while one experienced marginal improvement. Treatments ranged from 7 to 18 sessions. Specifically, the first patient reported substantial relief with a score reduction from 33 to 13; the second patient observed minimal change; the third patient\'s score decreased dramatically from 10 to 2 after eight sessions; the last patient had a score reduction from 21 to 12 after five sessions, but did not continue treatment for a second assessment.
UNASSIGNED: Acupuncture is a promising therapeutic approach for LIPN. However, larger and more thorough studies are needed to determine its full potential.
摘要：
■由于有效药物的可获得性有限，耐多药结核病（MDR-TB）和广泛耐药前结核病（Pre-XDR-TB）的治疗仍然具有挑战性。利奈唑胺已成为这些病例的有希望的治疗选择。然而,它的长期使用会导致并发症，如周围和视神经病变。针灸,中国传统医学的基石，已被证明是有效的治疗周围神经病变（PN）。这项研究探讨了针灸治疗利奈唑胺引起的周围神经病变（LIPN）的潜在益处。
■四个病人,年龄27至60岁，诊断为LIPN,接受每日针灸治疗。主要终点是评估针灸在减轻患者与LIPN相关的神经性疼痛中的功效。这主要是使用针灸治疗前后的简短形式McGill疼痛问卷（SF-MPQ）得分的变化来测量的。
■其中三名患者症状明显缓解，而一个人经历了边际改善。治疗范围为7至18个疗程。具体来说,第一例患者报告实质性缓解，得分从33降低到13；第二例患者观察到最小变化；第三例患者在八次治疗后得分从10急剧下降到2；最后一例患者在五次治疗后得分从21降低到12，但未继续治疗进行第二次评估.
■针灸是治疗LIPN的一种有前途的方法。然而,需要进行更大，更彻底的研究来确定其全部潜力。
■四个病人,年龄27至60岁，诊断为LIPN,接受每日针灸治疗。主要终点是评估针灸在减轻患者与LIPN相关的神经性疼痛中的功效。这主要是使用针灸治疗前后的简短形式McGill疼痛问卷（SF-MPQ）得分的变化来测量的。
■其中三名患者症状明显缓解，而一个人经历了边际改善。治疗范围为7至18个疗程。具体来说,第一例患者报告实质性缓解，得分从33降低到13；第二例患者观察到最小变化；第三例患者在八次治疗后得分从10急剧下降到2；最后一例患者在五次治疗后得分从21降低到12，但未继续治疗进行第二次评估.
■针灸是治疗LIPN的一种有前途的方法。然而,需要进行更大，更彻底的研究来确定其全部潜力。
