PDF(Pubmed)
Abstract：
The intestinal epithelium plays an important role in maintaining the intestinal barrier and facilitating nutrient absorption. It also serves as a critical physical barrier against the infiltration of foreign substances from the intestinal lumen into the circulation. Intestinal barrier dysfunction has been implicated in the development of several diseases. Isomaltooligosaccharides (IMOs), which are a type of dietary fiber, possess multiple health benefits. However, there is limited information regarding their efficacy against gastrointestinal diseases. This review explores the therapeutic potential of IMOs in obesity, diabetes mellitus, inflammatory bowel disease (IBD), hyperlipidemia, and constipation. High-fat diet (HFD)-induced obesity models have shown that IMOs, administered alone or in combination with other compounds, exhibit potent antiobesity effects, making them promising agents in the treatment of obesity and its associated complications. Moreover, IMOs exhibit preventive effects against HFD-induced metabolic dysfunction by modulating gut microbiota and short-chain fatty acid levels, thereby ameliorating symptoms. Furthermore, IMOs can reduce IBD and alleviate hyperlipidemia, as indicated by the reduced histological colitis scores and improved lipid profiles observed in clinical trials and animal studies. This review highlights IMOs as a versatile intervention strategy that can improve gastrointestinal health by modulating gut microbiota, immune responses, and metabolic parameters, providing a multifaceted approach to address the complex nature of gastrointestinal disorders.
摘要：
肠上皮在维持肠屏障和促进营养吸收方面起着重要作用。它还充当防止外来物质从肠腔渗入循环的关键物理屏障。肠屏障功能障碍与几种疾病的发展有关。低聚异麦芽寡糖(IMOs)，这是一种膳食纤维，拥有多种健康益处。然而,关于它们对胃肠道疾病的疗效的信息有限。这篇综述探讨了IMO在肥胖中的治疗潜力，糖尿病,炎症性肠病（IBD），高脂血症,还有便秘.高脂饮食(HFD)诱导的肥胖模型表明，单独或与其他化合物联合给药，表现出有效的抗肥胖作用，使它们成为治疗肥胖及其相关并发症的有前途的药物。此外，IMO通过调节肠道菌群和短链脂肪酸水平对HFD诱导的代谢功能障碍表现出预防作用，从而改善症状。此外，IMOs可以降低IBD，缓解高脂血症，正如在临床试验和动物研究中观察到的组织学结肠炎评分降低和脂质分布改善所表明的。这篇综述强调了IMO作为一种多功能干预策略，可以通过调节肠道微生物群改善胃肠道健康。免疫反应，和代谢参数，提供了一个多方面的方法来解决胃肠道疾病的复杂性。
