PDF(Pubmed)
Abstract：
Several randomized controlled trials (RCTs) have investigated the potential benefits of green tea on the inflammatory process in metabolic syndrome (MetS). However, the results are inconclusive and inconsistent. In the present study, we performed a literature review and meta-analysis to evaluate the effect of green tea supplementation on inflammatory markers [e.g., tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin-6 (IL-6)] among patients with MetS and related disorders. We systematically searched for relevant publications up to March 2022 in the PubMed, Scopus, Web of Science, and SciELO databases. The review was registered with PROSPERO (CRD42022320345). Mean differences with 95% confidence intervals were pooled on the basis of the random effects model to compare the effects of green tea with placebo. We used meta-regression and subgroup analyses to determine the cause of heterogeneity and performed study quality assessment using the Grading of Recommendations Assessment, Development, and Evaluation method. We assessed publication bias using funnel plots and Egger\'s tests. Out of the total 15 RCTs that were included in this systematic review, 12 were chosen for the meta-analysis. The results revealed that green tea significantly decreased TNF-α levels but did not affect CRP and IL-6 levels. Subgroup analysis showed that green tea supplementation in studies lasting ≤8 weeks significantly increased CRP levels. Furthermore, meta-regression analysis demonstrated a significant association between increasing IL-6 concentration and treatment duration. According to our meta-analysis, green tea was shown to considerably lower circulating TNF-α levels. To confirm these findings, carefully planned trials are required.
摘要：
一些随机对照试验（RCT）研究了绿茶对代谢综合征（MetS）炎症过程的潜在益处。然而,结果不确定且不一致。在本研究中,我们进行了文献综述和荟萃分析，以评估绿茶补充剂对炎症标志物的影响[例如，肿瘤坏死因子-α(TNF-α),C反应蛋白(CRP),和白细胞介素-6（IL-6）]在MetS和相关疾病患者中。我们系统地搜索了截至2022年3月的相关出版物，Scopus,WebofScience,和SciELO数据库。该评论已在PROSPERO（CRD42022320345）注册。基于随机效应模型汇集95%置信区间的平均差异,以比较绿茶与安慰剂的效应。我们使用荟萃回归和亚组分析来确定异质性的原因，并使用建议评估的分级进行研究质量评估。发展,和评价方法。我们使用漏斗图和Egger检验评估发表偏倚。在本系统评价中包含的15项随机对照试验中，选择12人进行荟萃分析。结果表明，绿茶显着降低TNF-α水平，但不影响CRP和IL-6水平。亚组分析显示，持续≤8周的研究中补充绿茶显著增加CRP水平。此外，荟萃回归分析显示IL-6浓度升高与治疗持续时间之间存在显著关联。根据我们的荟萃分析,绿茶显著降低循环TNF-α水平。为了证实这些发现,需要精心策划的试验。
