PDF(Pubmed)
Abstract：
UNASSIGNED: Obesity is a major risk factor for non-communicable diseases (NCDs), which has been the leading cause of death nowadays. The aim of this study is to examine the association between total changes in body mass index (BMI) across adulthood and the risk of obesity-related complex multimorbidity in elderly, characterizing the capacity of BMI waves in predicting major chronic diseases.
UNASSIGNED: In this retrospective study, 15,520 participants were analyzed from the National Health and Nutrition Examination Survey (NHANES) from 1999 and 2018. BMI was categorized as obesity (≥30.0 kg/m²), overweight (25.0-29.9 kg/m²), normal weight (18.5-24.9 kg/m²), and underweight (<18.5 kg/m²). Odds ratios (ORs) with 95% confidence interval (CIs) for the relationship between BMI change patterns and major health outcomes included hypertension, cancer, chronic obstructive pulmonary disease, cardiovascular disease, and diabetes, and population attributable fractions (PAFs) of BMI were evaluated.
UNASSIGNED: In comparison with participants who remained non-obese, those who are stable obese showed the highest risks of developing at least one chronic disease in later life, with odds ratios of 2.76 (95% CI: 2.20 to 3.45) from age 25 years to 10 years before baseline, 2.90 (2.28 to 3.68) from age 25 years to baseline, and 2.49 (2.11 to 2.95) in the 10-year period before baseline. Moving from non-obese to obese weight-change pattern in all periods (from age 25 years to 10 years before baseline: OR = 1.82; 95% CI, 1.57 to 2.11; from age 25 years to baseline: OR = 1.87; 95% CI, 1.59 to 2.19; from 10 years before baseline to baseline: OR = 1.62; 95% CI, 1.26 to 2.08) and moving from obese to non-obese, the 10-year period before baseline (OR = 1.89; 95% CI, 1.39 to 2.57) was associated with increased risk of chronic diseases. Midlife obesity status can explain the 8.6% risk of occurrence of the chronic diseases in elderly.
UNASSIGNED: Maintaining a stable healthy weight and losing weight in early adulthood and midlife are important for better life quality during the aging process. More effective strategies and policies to reduce the prevalence of obesity are needed.
UNASSIGNED: In this retrospective study, 15,520 participants were analyzed from the National Health and Nutrition Examination Survey (NHANES) from 1999 and 2018. BMI was categorized as obesity (≥30.0 kg/m²), overweight (25.0-29.9 kg/m²), normal weight (18.5-24.9 kg/m²), and underweight (<18.5 kg/m²). Odds ratios (ORs) with 95% confidence interval (CIs) for the relationship between BMI change patterns and major health outcomes included hypertension, cancer, chronic obstructive pulmonary disease, cardiovascular disease, and diabetes, and population attributable fractions (PAFs) of BMI were evaluated.
UNASSIGNED: In comparison with participants who remained non-obese, those who are stable obese showed the highest risks of developing at least one chronic disease in later life, with odds ratios of 2.76 (95% CI: 2.20 to 3.45) from age 25 years to 10 years before baseline, 2.90 (2.28 to 3.68) from age 25 years to baseline, and 2.49 (2.11 to 2.95) in the 10-year period before baseline. Moving from non-obese to obese weight-change pattern in all periods (from age 25 years to 10 years before baseline: OR = 1.82; 95% CI, 1.57 to 2.11; from age 25 years to baseline: OR = 1.87; 95% CI, 1.59 to 2.19; from 10 years before baseline to baseline: OR = 1.62; 95% CI, 1.26 to 2.08) and moving from obese to non-obese, the 10-year period before baseline (OR = 1.89; 95% CI, 1.39 to 2.57) was associated with increased risk of chronic diseases. Midlife obesity status can explain the 8.6% risk of occurrence of the chronic diseases in elderly.
UNASSIGNED: Maintaining a stable healthy weight and losing weight in early adulthood and midlife are important for better life quality during the aging process. More effective strategies and policies to reduce the prevalence of obesity are needed.
摘要：
■肥胖是非传染性疾病（NCDs）的主要危险因素，这一直是当今死亡的主要原因。这项研究的目的是检查成年后体重指数（BMI）的总变化与老年人肥胖相关的复杂多重性疾病的风险之间的关系。表征BMI波预测主要慢性疾病的能力。
■在这项回顾性研究中，从1999年和2018年的国家健康和营养检查调查（NHANES）分析了15520名参与者。BMI被归类为肥胖（≥30.0kg/m²），超重（25.0-29.9公斤/平方米），正常体重（18.5-24.9公斤/平方米），和体重不足（<18.5kg/m²）。BMI变化模式与主要健康结果包括高血压之间的关系的几率（ORs）和95%置信区间（CIs）。癌症,慢性阻塞性肺疾病,心血管疾病,糖尿病,并评估了BMI的人群归因分数（PAFs）。
■与保持非肥胖的参与者相比，那些稳定肥胖的人在以后的生活中出现至少一种慢性疾病的风险最高，基线前25岁至10岁的比值比为2.76（95%CI：2.20至3.45），2.90（2.28至3.68）从25岁到基线，和2.49（2.11至2.95）在基线前的10年期间。在所有时期（基线前从25岁到10岁：OR=1.82；95％CI，1.57至2.11；从25岁到基线：OR=1.87；95％CI，1.59至2.19；从基线前10年到基线：OR=1.62；95％CI，1.26至2.08）以及从肥胖到非肥胖，基线前10年(OR=1.89;95%CI,1.39~2.57)与慢性病风险增加相关.中年肥胖状况可以解释老年人发生慢性病的风险为8.6%。
■在成年早期和中年保持稳定的健康体重和减肥对于在衰老过程中更好的生活质量很重要。需要更有效的策略和政策来降低肥胖的患病率。
■在这项回顾性研究中，从1999年和2018年的国家健康和营养检查调查（NHANES）分析了15520名参与者。BMI被归类为肥胖（≥30.0kg/m²），超重（25.0-29.9公斤/平方米），正常体重（18.5-24.9公斤/平方米），和体重不足（<18.5kg/m²）。BMI变化模式与主要健康结果包括高血压之间的关系的几率（ORs）和95%置信区间（CIs）。癌症,慢性阻塞性肺疾病,心血管疾病,糖尿病,并评估了BMI的人群归因分数（PAFs）。
■与保持非肥胖的参与者相比，那些稳定肥胖的人在以后的生活中出现至少一种慢性疾病的风险最高，基线前25岁至10岁的比值比为2.76（95%CI：2.20至3.45），2.90（2.28至3.68）从25岁到基线，和2.49（2.11至2.95）在基线前的10年期间。在所有时期（基线前从25岁到10岁：OR=1.82；95％CI，1.57至2.11；从25岁到基线：OR=1.87；95％CI，1.59至2.19；从基线前10年到基线：OR=1.62；95％CI，1.26至2.08）以及从肥胖到非肥胖，基线前10年(OR=1.89;95%CI,1.39~2.57)与慢性病风险增加相关.中年肥胖状况可以解释老年人发生慢性病的风险为8.6%。
■在成年早期和中年保持稳定的健康体重和减肥对于在衰老过程中更好的生活质量很重要。需要更有效的策略和政策来降低肥胖的患病率。
