PDF(Pubmed)
Abstract：
UNASSIGNED: Craniopharyngiomas (CPs) are rare, low-grade tumors characterized by a range of debilitating symptoms. Most of the existing literature reports postoperative outcomes of the different treatment modalities of childhood CP. However, few studies have reported the impact of these different treatment methods on the quality of life (QoL) of survivors of childhood CP. Therefore, we aim to assess the correlation between different surgical modalities on the QoL of patients with childhood CP from a lower-middle-income country.
UNASSIGNED: Twenty-nine survivors who underwent treatment for CP were included in the study. The selected patients had either been managed with complete resection, debulking, or placement of an Ommaya reservoir. QoL was assessed by the pediatric quality of life (PedsQL) questionnaire. The effect of the different treatment modalities on the QoL was assessed.
UNASSIGNED: Mean follow-up was 4.4 ± 2.19 years. The type of surgery was significantly related to the mean PedsQL scores for the total score as well as each of the individual domain scores (P < 0.001). Complete resection of the tumor resulted in the lowest mean (standard deviation) PedsQL total score of 56.6 ± 7.12 compared to the Ommaya reservoir with biopsy (83.3 ± 5.69) and debulking (93.8 ± 3.37) (P < 0.001).
UNASSIGNED: There was a significant effect of the type of surgical treatment on the QoL of the survivors of childhood CP. It is important to consider the long-term outcomes in addition to immediate postoperative outcomes when deciding on a treatment strategy while managing children with CP.
UNASSIGNED: Twenty-nine survivors who underwent treatment for CP were included in the study. The selected patients had either been managed with complete resection, debulking, or placement of an Ommaya reservoir. QoL was assessed by the pediatric quality of life (PedsQL) questionnaire. The effect of the different treatment modalities on the QoL was assessed.
UNASSIGNED: Mean follow-up was 4.4 ± 2.19 years. The type of surgery was significantly related to the mean PedsQL scores for the total score as well as each of the individual domain scores (P < 0.001). Complete resection of the tumor resulted in the lowest mean (standard deviation) PedsQL total score of 56.6 ± 7.12 compared to the Ommaya reservoir with biopsy (83.3 ± 5.69) and debulking (93.8 ± 3.37) (P < 0.001).
UNASSIGNED: There was a significant effect of the type of surgical treatment on the QoL of the survivors of childhood CP. It is important to consider the long-term outcomes in addition to immediate postoperative outcomes when deciding on a treatment strategy while managing children with CP.
摘要：
■颅咽管瘤（CPs）很少见，以一系列衰弱症状为特征的低度肿瘤。现有文献大多报道了儿童CP不同治疗方式的术后结局。然而,很少有研究报道这些不同治疗方法对儿童CP幸存者生活质量(QoL)的影响.因此,我们旨在评估不同手术方式对来自中低收入国家的儿童CP患者QoL的相关性.
■29名接受CP治疗的幸存者被纳入研究。选定的患者要么接受了完全切除的治疗，扣减，或放置Ommaya水库。通过儿科生活质量（PedsQL）问卷评估QoL。评估了不同治疗方式对QoL的影响。
■平均随访时间为4.4±2.19年。手术类型与总分的平均PedsQL评分以及每个单独领域评分显著相关(P<0.001)。与活检（83.3±5.69）和减积（93.8±3.37）的Ommaya水库相比，肿瘤的完全切除导致最低的平均（标准偏差）PedsQL总分为56.6±7.12（P<0.001）。
■手术治疗类型对儿童CP幸存者的QoL有显著影响。在管理CP儿童时，在决定治疗策略时，除了术后近期结果外，还必须考虑长期结果。
■29名接受CP治疗的幸存者被纳入研究。选定的患者要么接受了完全切除的治疗，扣减，或放置Ommaya水库。通过儿科生活质量（PedsQL）问卷评估QoL。评估了不同治疗方式对QoL的影响。
■平均随访时间为4.4±2.19年。手术类型与总分的平均PedsQL评分以及每个单独领域评分显著相关(P<0.001)。与活检（83.3±5.69）和减积（93.8±3.37）的Ommaya水库相比，肿瘤的完全切除导致最低的平均（标准偏差）PedsQL总分为56.6±7.12（P<0.001）。
■手术治疗类型对儿童CP幸存者的QoL有显著影响。在管理CP儿童时，在决定治疗策略时，除了术后近期结果外，还必须考虑长期结果。
