PDF(Pubmed)
Abstract：
UNASSIGNED: Radiation-induced changes (RICs) post-stereotactic radiosurgery (SRS) critically influence outcomes in arteriovenous malformation (AVM) treatments. This study aimed to identify predictors of RICs, described the types and severity of RICs, and assessed their impact on patient\'s functional outcomes to enhance risk assessment and treatment planning for AVM patients.
UNASSIGNED: This retrospective study analyzed 87 AVM patients who underwent SRS at Hospital Kuala Lumpur between January 2015 and December 2020. RICs were identified through detailed magnetic resonance imaging evaluations, and predictive factors were determined using multiple logistic regression. Functional outcomes were assessed with the modified Rankin scale (mRS).
UNASSIGNED: Among the cohort, 40.2% developed RICs, with radiological RICs in 33.3%, symptomatic RICs in 5.7%, and permanent RICs in 1.1%. Severity categorization revealed 25.3% as Grade I, 13.8% as Grade II, and 1.1% as Grade III. Notably, higher Pollock-Flickinger scores and eloquence location were significant predictors of RIC occurrence. There was a significant improvement in functional outcomes post-SRS, with a marked decrease in non-favorable mRS scores from 8.0% pre-SRS to 1.1% post-SRS (P = 0.031).
UNASSIGNED: The study identified the eloquence location and Pollock-Flickinger scores as predictors of RICs post-SRS. The significant reduction in non-favorable mRS scores post-SRS underscores the efficacy of SRS in improving patient outcomes. Their results highlighted the importance of personalized treatment planning, focusing on precise strategies to optimize patient outcomes in AVM management, reducing adverse effects while improving functional outcomes.
UNASSIGNED: This retrospective study analyzed 87 AVM patients who underwent SRS at Hospital Kuala Lumpur between January 2015 and December 2020. RICs were identified through detailed magnetic resonance imaging evaluations, and predictive factors were determined using multiple logistic regression. Functional outcomes were assessed with the modified Rankin scale (mRS).
UNASSIGNED: Among the cohort, 40.2% developed RICs, with radiological RICs in 33.3%, symptomatic RICs in 5.7%, and permanent RICs in 1.1%. Severity categorization revealed 25.3% as Grade I, 13.8% as Grade II, and 1.1% as Grade III. Notably, higher Pollock-Flickinger scores and eloquence location were significant predictors of RIC occurrence. There was a significant improvement in functional outcomes post-SRS, with a marked decrease in non-favorable mRS scores from 8.0% pre-SRS to 1.1% post-SRS (P = 0.031).
UNASSIGNED: The study identified the eloquence location and Pollock-Flickinger scores as predictors of RICs post-SRS. The significant reduction in non-favorable mRS scores post-SRS underscores the efficacy of SRS in improving patient outcomes. Their results highlighted the importance of personalized treatment planning, focusing on precise strategies to optimize patient outcomes in AVM management, reducing adverse effects while improving functional outcomes.
摘要：
■立体定向放射外科（SRS）后放射诱发的变化（RIC）严重影响动静脉畸形（AVM）治疗的结局。本研究旨在确定RIC的预测因子，描述了RIC的类型和严重性，并评估其对患者功能结局的影响，以加强AVM患者的风险评估和治疗计划。
这项回顾性研究分析了2015年1月至2020年12月在吉隆坡医院接受SRS的87例AVM患者。通过详细的磁共振成像评估确定RIC，和预测因素使用多元逻辑回归确定。使用改良的Rankin量表（mRS）评估功能结果。
■在队列中，40.2%已开发RIC，放射性RIC为33.3%，有症状的RIC为5.7%，永久RIC为1.1%。严重性分类显示25.3%为一级，13.8%为二级，1.1%为三级。值得注意的是,较高的Pollock-Flickinger评分和口才位置是RIC发生的重要预测因子。SRS后的功能结果有显著改善，非良好的mRS评分从SRS前的8.0%明显降低至SRS后的1.1%(P=0.031)。
■该研究确定了口才位置和Pollock-Flickinger得分作为SRS后RIC的预测因子。SRS后不良mRS评分的显着降低强调了SRS在改善患者预后方面的功效。他们的结果强调了个性化治疗计划的重要性，专注于精确的策略，以优化AVM管理中的患者结果，减少不良反应，同时改善功能结果。
这项回顾性研究分析了2015年1月至2020年12月在吉隆坡医院接受SRS的87例AVM患者。通过详细的磁共振成像评估确定RIC，和预测因素使用多元逻辑回归确定。使用改良的Rankin量表（mRS）评估功能结果。
■在队列中，40.2%已开发RIC，放射性RIC为33.3%，有症状的RIC为5.7%，永久RIC为1.1%。严重性分类显示25.3%为一级，13.8%为二级，1.1%为三级。值得注意的是,较高的Pollock-Flickinger评分和口才位置是RIC发生的重要预测因子。SRS后的功能结果有显著改善，非良好的mRS评分从SRS前的8.0%明显降低至SRS后的1.1%(P=0.031)。
■该研究确定了口才位置和Pollock-Flickinger得分作为SRS后RIC的预测因子。SRS后不良mRS评分的显着降低强调了SRS在改善患者预后方面的功效。他们的结果强调了个性化治疗计划的重要性，专注于精确的策略，以优化AVM管理中的患者结果，减少不良反应，同时改善功能结果。
