PDF(Pubmed)
Abstract：
UNASSIGNED: Brucellosis is a zoonotic disease that is widely spread across the globe, with the number of cases increasing annually. Spinal brucellosis is known to affect about half of patients with brucellosis. Nevertheless, data on the optimal antibiotic regimens for spinal brucellosis are limited. Therefore, this study aims to compare antibiotic treatment regimens for spinal brucellosis at our center in Makkah, Saudi Arabia.
UNASSIGNED: This is a retrospective cohort study of an 11-year period from 2010 to 2021 conducted at a single center in Makkah, Saudi Arabia. All patients with spinal brucellosis were included. Patients were excluded if the duration of the received antibiotic regimen or follow-up was poorly documented. Data analysis was conducted using RStudio (R version 4.1.1). Categorical variables of each regimen used by the patients were presented as frequencies and percentages, while numerical variables were summarized using the median and interquartile range (IQR).
UNASSIGNED: A total of 35 patients were included; the median (IQR) age of the patients was 58.0 (48.0 to 63.0) years. The most frequently reported symptoms upon admission included low back pain (83.3%). The most frequently administered regimen was the combination of streptomycin + doxycycline + rifampicin (SDR) (20 patients, 55.6%), followed by the combination of streptomycin + rifampicin + trimethoprim/sulfamethoxazole (SRT) (eight patients, 22.2%). Overall, out of the total 35 patients who received first-line treatment, only six patients experienced therapy failure. Out of the total six patients who experienced first-line treatment failure with SDR (five patients, 83%) and SDT (one patient, 17%), surgery was indicated for three patients. Surgical intervention was deemed necessary in 12 patients (34%). Three patients chose not to undergo surgical intervention but still showed complete improvement upon completing the treatment duration. One patient experienced a postoperative complication, resulting in paraplegia.
UNASSIGNED: In this study, we found that among 35 patients, treatment failure was observed only in six patients who received triple therapy. In addition, surgical intervention was indicated in 12 patients; however, three patients refused surgery and improved ultimately after changing or extending the duration of the antibiotic regimen.
UNASSIGNED: This is a retrospective cohort study of an 11-year period from 2010 to 2021 conducted at a single center in Makkah, Saudi Arabia. All patients with spinal brucellosis were included. Patients were excluded if the duration of the received antibiotic regimen or follow-up was poorly documented. Data analysis was conducted using RStudio (R version 4.1.1). Categorical variables of each regimen used by the patients were presented as frequencies and percentages, while numerical variables were summarized using the median and interquartile range (IQR).
UNASSIGNED: A total of 35 patients were included; the median (IQR) age of the patients was 58.0 (48.0 to 63.0) years. The most frequently reported symptoms upon admission included low back pain (83.3%). The most frequently administered regimen was the combination of streptomycin + doxycycline + rifampicin (SDR) (20 patients, 55.6%), followed by the combination of streptomycin + rifampicin + trimethoprim/sulfamethoxazole (SRT) (eight patients, 22.2%). Overall, out of the total 35 patients who received first-line treatment, only six patients experienced therapy failure. Out of the total six patients who experienced first-line treatment failure with SDR (five patients, 83%) and SDT (one patient, 17%), surgery was indicated for three patients. Surgical intervention was deemed necessary in 12 patients (34%). Three patients chose not to undergo surgical intervention but still showed complete improvement upon completing the treatment duration. One patient experienced a postoperative complication, resulting in paraplegia.
UNASSIGNED: In this study, we found that among 35 patients, treatment failure was observed only in six patients who received triple therapy. In addition, surgical intervention was indicated in 12 patients; however, three patients refused surgery and improved ultimately after changing or extending the duration of the antibiotic regimen.
摘要：
■布鲁氏菌病是一种人畜共患疾病，在全球范围内广泛传播，病例数量逐年增加。已知脊柱布鲁氏菌病会影响约一半的布鲁氏菌病患者。然而，关于脊髓布鲁氏菌病最佳抗生素治疗方案的数据有限.因此,这项研究旨在比较我们麦加中心对脊柱布鲁氏菌病的抗生素治疗方案，沙特阿拉伯。
■这是一项2010年至2021年的11年回顾性队列研究，在麦加的一个中心进行，沙特阿拉伯。纳入所有脊髓布鲁氏菌病患者。如果接受抗生素方案或随访的持续时间记录不佳，则排除患者。使用RStudio(R版本4.1.1)进行数据分析。患者使用的每种方案的分类变量以频率和百分比表示，而使用中位数和四分位距（IQR）总结数字变量。
■共纳入35例患者；患者的中位年龄（IQR）为58.0（48.0至63.0）岁。入院时最常见的症状包括腰背痛（83.3％）。最常见的给药方案是链霉素+多西环素+利福平（SDR）的组合（20例患者，55.6%），其次是链霉素+利福平+甲氧苄啶/磺胺甲恶唑（SRT）（8例，22.2%）。总的来说,在接受一线治疗的35名患者中，只有6例患者出现治疗失败.在总共六名经历过SDR一线治疗失败的患者中(五名患者，83%)和SDT(一名患者，17%），3例患者需要接受手术治疗.12例患者（34%）认为有必要进行手术干预。三名患者选择不接受手术干预，但在完成治疗持续时间后仍显示出完全改善。一名患者出现术后并发症,导致截瘫.
■在这项研究中，我们发现在35个病人中,仅在6例接受三联疗法的患者中观察到治疗失败.此外,12例患者接受了手术干预；然而，3例患者拒绝手术,并在改变或延长抗生素治疗方案后最终好转.
■这是一项2010年至2021年的11年回顾性队列研究，在麦加的一个中心进行，沙特阿拉伯。纳入所有脊髓布鲁氏菌病患者。如果接受抗生素方案或随访的持续时间记录不佳，则排除患者。使用RStudio(R版本4.1.1)进行数据分析。患者使用的每种方案的分类变量以频率和百分比表示，而使用中位数和四分位距（IQR）总结数字变量。
■共纳入35例患者；患者的中位年龄（IQR）为58.0（48.0至63.0）岁。入院时最常见的症状包括腰背痛（83.3％）。最常见的给药方案是链霉素+多西环素+利福平（SDR）的组合（20例患者，55.6%），其次是链霉素+利福平+甲氧苄啶/磺胺甲恶唑（SRT）（8例，22.2%）。总的来说,在接受一线治疗的35名患者中，只有6例患者出现治疗失败.在总共六名经历过SDR一线治疗失败的患者中(五名患者，83%)和SDT(一名患者，17%），3例患者需要接受手术治疗.12例患者（34%）认为有必要进行手术干预。三名患者选择不接受手术干预，但在完成治疗持续时间后仍显示出完全改善。一名患者出现术后并发症,导致截瘫.
■在这项研究中，我们发现在35个病人中,仅在6例接受三联疗法的患者中观察到治疗失败.此外,12例患者接受了手术干预；然而，3例患者拒绝手术,并在改变或延长抗生素治疗方案后最终好转.
