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Abstract：
Introduction Controlling the partial pressure of carbon dioxide (PaCO 2 ) is an important consideration in patients with intracranial steno-occlusive disease to avoid reductions in critical perfusion from vasoconstriction due to hypocapnia, or reductions in blood flow due to steal physiology during hypercapnia. However, the normal range for resting PCO 2 in this patient population is not known. Therefore, we investigated the variability in resting end-tidal PCO 2 (P ET CO 2 ) in patients with intracranial steno-occlusive disease and the impact of revascularization on resting P ET CO 2 in these patients. Setting and Design Tertiary care center, retrospective chart review Materials and Methods We collected resting P ET CO 2 values in adult patients with intracranial steno-occlusive disease who presented to our institution between January 2010 and June 2021. We also explored postrevascularization changes in resting P ET CO 2 in a subset of patients. Results Two hundred and twenty-seven patients were included [moyamoya vasculopathy ( n = 98) and intracranial atherosclerotic disease ( n = 129)]. In the whole cohort, mean ± standard deviation resting P ET CO 2 was 37.8 ± 3.9 mm Hg (range: 26-47). In patients with moyamoya vasculopathy and intracranial atherosclerotic disease, resting P ET CO 2 was 38.4 ± 3.6 mm Hg (range: 28-47) and 37.4 ± 4.1 mm Hg (range: 26-46), respectively. A trend was identified suggesting increasing resting P ET CO 2 after revascularization in patients with low preoperative resting P ET CO 2 (<38 mm Hg) and decreasing resting P ET CO 2 after revascularization in patients with high preoperative resting P ET CO 2 (>38 mm Hg). Conclusion This study demonstrates that resting P ET CO 2 in patients with intracranial steno-occlusive disease is highly variable. In some patients, there was a change in resting P ET CO 2 after a revascularization procedure.
摘要：
介绍控制二氧化碳分压（PaCO2）是颅内狭窄闭塞性疾病患者的重要考虑因素，以避免由于低碳酸血症引起的血管收缩而导致的临界灌注减少，或在高碳酸血症期间由于偷窃生理而导致的血流量减少。然而,该患者人群中静息PCO2的正常范围未知.因此,我们调查了颅内狭窄闭塞性疾病患者静息呼气末PCO2(PETCO2)的变异性,以及血运重建对这些患者静息PETCO2的影响.三级护理中心的设置和设计，材料与方法我们收集了2010年1月至2021年6月期间到我院就诊的颅内狭窄闭塞性疾病成年患者的静息PETCO2值.我们还探讨了部分患者静息PETCO2的血管化后变化。结果共纳入27例[烟雾状血管病变（n=98）和颅内动脉粥样硬化性疾病（n=129）]。在整个队列中，静息PETCO2的平均值±标准偏差为37.8±3.9mmHg（范围：26-47）。在患有烟雾血管病变和颅内动脉粥样硬化疾病的患者中，静息PETCO2为38.4±3.6mmHg（范围：28-47）和37.4±4.1mmHg（范围：26-46），分别。发现趋势表明，术前静息PETCO2低（<38mmHg）的患者血运重建后静息PETCO2增加，术前静息PETCO2高（>38mmHg）的患者血运重建后静息PETCO2降低。结论本研究表明，颅内狭窄闭塞性疾病患者的静息PETCO2变化很大。在一些患者中，血运重建手术后静息PETCO2有变化。
