PDF(Pubmed)
Abstract：
Lady Windermere syndrome (LWS) is a disease caused by a non-tuberculous Mycobacterium (NTM) that is commonly found in thin women who voluntarily suppress their cough reflex. The NTM that causes this syndrome is Mycobacterium avium complex, an organism commonly present in chlorinated city water and soil. Patients with LWS are tall, lean, elderly white women. We report a case of an immunocompetent 81-year-old thin Puerto Rican female with a recurrent cough since childhood, who was misdiagnosed with tuberculosis (TB) and prophylactically treated. While the patient fitted the clinical picture of NTM pulmonary infection based on symptoms, imaging, and microbiologic findings, her demography and morphologic features were not completely consistent with published findings. The incidence and prevalence of NTM lung disease are rising worldwide due to the aging population, increased use of immunosuppressive medications, and prevalence of chronic pulmonary obstructive disease and bronchiectasis. The goal of this report is to increase awareness of LWS as one of the diagnoses that should be considered in patients presenting with clinical findings resembling TB and bring attention to the different clinical characteristics this patient with LWS possessed.
摘要：
温德米尔夫人综合征（LWS）是一种由非结核分枝杆菌（NTM）引起的疾病，常见于自愿抑制咳嗽反射的瘦女性中。导致这种综合征的NTM是鸟分枝杆菌复合体，一种通常存在于城市水和土壤中的生物。LWS患者很高，精益，老年白人妇女我们报告了一例具有免疫能力的81岁薄薄的波多黎各女性，从小就反复咳嗽，谁被误诊为结核病（TB）和预防性治疗。虽然患者根据症状符合NTM肺部感染的临床表现，成像,和微生物学发现，她的人口学和形态学特征与已发表的研究结果并不完全一致.由于人口老龄化，NTM肺病的发病率和患病率在全球范围内呈上升趋势，增加使用免疫抑制药物，慢性阻塞性肺疾病和支气管扩张的患病率。本报告的目的是提高对LWS的认识，将其作为临床发现与结核病相似的患者应考虑的诊断之一，并引起对LWS患者所具有的不同临床特征的关注。
