PDF(Pubmed)
Abstract：
UNASSIGNED: Immune cells are dynamic in the inflammatory environment and play a key role in eradicating periodontal pathogens, modulating immune responses, and instigating tissue destruction. Identifying specific immune cell phenotypes associated with periodontitis risk is essential for targeted immunotherapeutic interventions. However, the role of certain specific immune cell phenotypes in the development of periodontitis is unknown. Mendelian randomization offers a novel approach to reveal causality and address potential confounding factors through genetic instruments.
UNASSIGNED: This two-sample Mendelian randomization study assessed the causal relationship between 731 immune cell phenotypes and periodontitis using the inverse variance weighting method with the GWAS catalog genetic database. Methodological robustness was ensured through Cochran\'s Q test, MR-Egger regression, MR-PRESSO, and Leave-One-Out analysis.
UNASSIGNED: 14 immune cell phenotypes showed potential positive causal associations with periodontitis risk (p < 0.05), suggesting an increased risk, while 11 immune cell phenotypes exhibited potential negative causal associations (p < 0.05), indicating a reduced risk. No significant heterogeneity or pleiotropy was observed.
UNASSIGNED: This study underscores certain immune cell types as potential periodontitis risk biomarkers, laying a theoretical foundation for future individualized treatment and precision medicine development.
UNASSIGNED: This two-sample Mendelian randomization study assessed the causal relationship between 731 immune cell phenotypes and periodontitis using the inverse variance weighting method with the GWAS catalog genetic database. Methodological robustness was ensured through Cochran\'s Q test, MR-Egger regression, MR-PRESSO, and Leave-One-Out analysis.
UNASSIGNED: 14 immune cell phenotypes showed potential positive causal associations with periodontitis risk (p < 0.05), suggesting an increased risk, while 11 immune cell phenotypes exhibited potential negative causal associations (p < 0.05), indicating a reduced risk. No significant heterogeneity or pleiotropy was observed.
UNASSIGNED: This study underscores certain immune cell types as potential periodontitis risk biomarkers, laying a theoretical foundation for future individualized treatment and precision medicine development.
摘要：
■免疫细胞在炎症环境中是动态的，在根除牙周病原体中起关键作用，调节免疫反应，并煽动组织破坏。确定与牙周炎风险相关的特异性免疫细胞表型对于靶向免疫治疗干预至关重要。然而,某些特异性免疫细胞表型在牙周炎发展中的作用尚不清楚。孟德尔随机化提供了一种新的方法来揭示因果关系并通过遗传工具解决潜在的混杂因素。
■这项双样本孟德尔随机化研究使用与GWAS目录遗传数据库的逆方差加权方法评估了731种免疫细胞表型与牙周炎之间的因果关系。通过Cochran的Q检验确保了方法学的稳健性，MR-Egger回归，MR-PRESSO,和留置权分析。
■14种免疫细胞表型显示出与牙周炎风险的潜在正相关（p<0.05），表明风险增加，而11种免疫细胞表型表现出潜在的负因果关联(p<0.05)，表明风险降低。没有观察到显著的异质性或多效性。
这项研究强调某些免疫细胞类型是潜在的牙周炎风险生物标志物，为未来的个体化治疗和精准医学发展奠定理论基础。
■这项双样本孟德尔随机化研究使用与GWAS目录遗传数据库的逆方差加权方法评估了731种免疫细胞表型与牙周炎之间的因果关系。通过Cochran的Q检验确保了方法学的稳健性，MR-Egger回归，MR-PRESSO,和留置权分析。
■14种免疫细胞表型显示出与牙周炎风险的潜在正相关（p<0.05），表明风险增加，而11种免疫细胞表型表现出潜在的负因果关联(p<0.05)，表明风险降低。没有观察到显著的异质性或多效性。
这项研究强调某些免疫细胞类型是潜在的牙周炎风险生物标志物，为未来的个体化治疗和精准医学发展奠定理论基础。
