PDF(Pubmed)
Abstract：
UNASSIGNED: Intravenous sedation (IVS) with propofol (PPF) is commonly performed in dental treatment, particular in patients with dentophobia, with gag reflex, or undergoing implant surgeries, as PPF has the advantages of rapid induction and recovery. However, PPF and other intravenous sedatives may cause respiratory depression. Thus, IVS with PPF requires oxygen administration. But airway burn may occur when high-concentration oxygen is stored in the oral cavity and catches fire. For these reasons, the present study aimed to elucidate the changes in oxygen concentration (OC) under IVS with PPF and oxygen administration.
UNASSIGNED: Nineteen healthy male volunteers participated in the study. None of them had missing teeth, nasal congestion, or temporomandibular joint dysfunction. They were sedated with a continuous PPF infusion dose of 6 mg/kg/hr for 25 min, followed by administration of 3 L/min oxygen via a nasal cannula. The OC was measured at two sites, namely, the median maxillary anterior teeth (MMAT) and median maxillary soft palate (MMSP), before PPF infusion (baseline) and 14, 15-18 (Term 1), 19, and 20-23 (Term 2) min after the start of infusion.
UNASSIGNED: Compared with the values at baseline, the OC in the MMSP significantly increased at each time point, whereas the OC in the MMAT significantly increased at Term 2. Furthermore, in the comparison of the OC before and after the use of a mouth prop, the OC exhibited an upward trend, but no statistically significant differences were observed between the two time points in the MMAT and MMSP. In IVS with PPF and oxygen administration, the OC in the pharynx increases as the sedative level deepens.
UNASSIGNED: Oxygen administration should be temporarily discontinued, and suction should be performed to decrease the OC in the oral cavity when sparking procedures during IVS with PPF and oxygen administration are performed.
UNASSIGNED: Nineteen healthy male volunteers participated in the study. None of them had missing teeth, nasal congestion, or temporomandibular joint dysfunction. They were sedated with a continuous PPF infusion dose of 6 mg/kg/hr for 25 min, followed by administration of 3 L/min oxygen via a nasal cannula. The OC was measured at two sites, namely, the median maxillary anterior teeth (MMAT) and median maxillary soft palate (MMSP), before PPF infusion (baseline) and 14, 15-18 (Term 1), 19, and 20-23 (Term 2) min after the start of infusion.
UNASSIGNED: Compared with the values at baseline, the OC in the MMSP significantly increased at each time point, whereas the OC in the MMAT significantly increased at Term 2. Furthermore, in the comparison of the OC before and after the use of a mouth prop, the OC exhibited an upward trend, but no statistically significant differences were observed between the two time points in the MMAT and MMSP. In IVS with PPF and oxygen administration, the OC in the pharynx increases as the sedative level deepens.
UNASSIGNED: Oxygen administration should be temporarily discontinued, and suction should be performed to decrease the OC in the oral cavity when sparking procedures during IVS with PPF and oxygen administration are performed.
摘要：
■丙泊酚（PPF）静脉镇静（IVS）通常在牙科治疗中进行，特别是在患有恐惧症的患者中，呕吐反射，或者接受植入手术，PPF具有快速诱导和恢复的优点。然而,PPF和其他静脉镇静剂可引起呼吸抑制。因此，具有PPF的IVS需要给氧。但是，当高浓度的氧气储存在口腔中并着火时，可能会发生气道灼伤。由于这些原因,本研究旨在阐明PPF和氧气给药IVS下氧气浓度（OC）的变化。
■19名健康男性志愿者参加了这项研究。他们都没有牙齿缺失，鼻塞,或颞下颌关节功能障碍。他们用6mg/kg/hr的PPF连续输注剂量镇静25分钟，然后通过鼻插管给予3L/min的氧气。在两个地点测量了OC，即,正中上颌前牙（MMAT）和正中上颌软腭（MMSP），PPF输注前（基线）和14，15-18（第1项），输注开始后19和20-23（第2项）分钟。
■与基线值相比，MMSP中的OC在每个时间点均显着增加，而在第2期，MMAT中的OC显著增加。此外，在使用口腔支柱前后的OC比较中，OC呈上升趋势，但是在MMAT和MMSP的两个时间点之间没有观察到统计学上的显着差异。在使用PPF和氧气给药的IVS中，咽部的OC随着镇静水平的加深而增加。
■应暂时停止氧气给药，在进行PPF和氧气给药的IVS过程中，应进行抽吸以降低口腔中的OC。
■19名健康男性志愿者参加了这项研究。他们都没有牙齿缺失，鼻塞,或颞下颌关节功能障碍。他们用6mg/kg/hr的PPF连续输注剂量镇静25分钟，然后通过鼻插管给予3L/min的氧气。在两个地点测量了OC，即,正中上颌前牙（MMAT）和正中上颌软腭（MMSP），PPF输注前（基线）和14，15-18（第1项），输注开始后19和20-23（第2项）分钟。
■与基线值相比，MMSP中的OC在每个时间点均显着增加，而在第2期，MMAT中的OC显著增加。此外，在使用口腔支柱前后的OC比较中，OC呈上升趋势，但是在MMAT和MMSP的两个时间点之间没有观察到统计学上的显着差异。在使用PPF和氧气给药的IVS中，咽部的OC随着镇静水平的加深而增加。
■应暂时停止氧气给药，在进行PPF和氧气给药的IVS过程中，应进行抽吸以降低口腔中的OC。
