PDF(Pubmed)
Abstract：
Depression is one of the world\'s most prevalent mental disorders and its treatment remains suboptimal. Depression is a systemic disease with highly complex biological mechanisms. Emerging evidence points towards the involvement of mitochondria, microbiome and vitamins in its pathophysiology. Mitochondrial energy production was shown to be lowered in patients with depression. Mitochondrial energy production depends on vitamins, which are available from food, but are also synthesized by the gut microbiota. Several studies reported altered vitamin levels as well as changes in the gut microbiome composition and its vitamin metabolism in patients with depression. Therefore, the question of a connection between mitochondria and gut microbiome and vitamins influencing the mental health arises. This review aims to systematically investigate a combination of the topics - depression, mitochondria, microbiome, and vitamins - to generate an overview of a novel yet extremely complex and interconnected research field. A systematic literature search yielded 34 articles, and the results were summarized and bundled to develop this new integrative perspective on mitochondrial function mediated by the microbiome and microbiome-derived vitamins in depression. Furthermore, by discussing the research gaps this review aims to encourage innovative research approaches to better understand the biology of depression, which could result in optimized therapeutic approaches.
摘要：
抑郁症是世界上最普遍的精神障碍之一，其治疗仍然不理想。抑郁症是一种具有高度复杂的生物学机制的全身性疾病。新出现的证据指向线粒体的参与，病理生理学中的微生物组和维生素组。抑郁症患者的线粒体能量产生降低。线粒体能量的产生依赖于维生素,可以从食物中获得，但也由肠道微生物群合成。一些研究报告了抑郁症患者的维生素水平改变以及肠道微生物组组成及其维生素代谢的变化。因此,线粒体和肠道微生物组和影响心理健康的维生素之间的联系的问题出现了。这篇综述旨在系统地研究主题的组合-抑郁症，线粒体,微生物组,和维生素-生成一个新颖但极其复杂和相互关联的研究领域的概述。系统的文献检索产生了34篇文章，并对结果进行了总结和捆绑，以发展这种关于抑郁症中微生物组和微生物组来源的维生素介导的线粒体功能的新综合观点。此外，通过讨论研究差距，这篇综述旨在鼓励创新的研究方法，以更好地了解抑郁症的生物学，这可能导致优化的治疗方法。
