PDF(Pubmed)
Abstract：
Recent advancements in various technologies have shed light on the critical role of metabolism in immune cells, paving the way for innovative disease treatment strategies through immunometabolism modulation. This review emphasizes the glucose metabolism of myeloid-derived suppressor cells (MDSCs), an emerging pivotal immunosuppressive factor especially within the tumor microenvironment. MDSCs, an immature and heterogeneous myeloid cell population, act as a double-edged sword by exacerbating tumors or mitigating inflammatory diseases through their immune-suppressive functions. Numerous recent studies have centered on glycolysis of MDSC, investigating the regulation of altered glycolytic pathways to manage diseases. However, the specific changes in MDSC glycolysis and their exact functions continue to be areas of ongoing discussion yet. In this paper, we review a range of current findings, including the latest research on the alteration of glycolysis in MDSCs, the consequential functional alterations in these cells, and the outcomes of attempts to modulate MDSC functions by regulating glycolysis. Ultimately, we will provide insights into whether these research efforts could be translated into clinical applications.
摘要：
各种技术的最新进展揭示了新陈代谢在免疫细胞中的关键作用，通过免疫代谢调节为创新的疾病治疗策略铺平道路。这篇综述强调了骨髓来源的抑制细胞（MDSCs）的葡萄糖代谢，一种新兴的关键免疫抑制因子，尤其是在肿瘤微环境中。MDSCs,未成熟和异质的骨髓细胞群，充当双刃剑，通过免疫抑制功能加重肿瘤或减轻炎性疾病。最近的许多研究都集中在MDSC的糖酵解上，研究改变糖酵解途径的调节以管理疾病。然而,MDSC糖酵解的具体变化及其确切功能仍然是正在进行讨论的领域。在本文中,我们回顾了一系列当前的发现，包括关于MDSCs糖酵解改变的最新研究，这些细胞的相应功能改变，以及通过调节糖酵解来调节MDSC功能的尝试结果。最终,我们将提供这些研究工作是否可以转化为临床应用的见解。
