PDF(Pubmed)
Abstract：
Cirrhotic cardiomyopathy represents a syndrome of cardiac dysfunction associated with advanced liver disease. It is the result of complex pathophysiological processes that complicate the course of the disease, and is generally associated with a poor prognosis. Pathophysiologically, portal hypertension is the key factor leading to hyperdynamic circulation, via over-activation of the neurohumoral axis. Intestinal obstruction, subclinical inflammation and hepatocellular insufficiency, with defective synthesis or metabolism of several vasoactive mediators, are essential components of this process. Since it is usually unapparent at rest and only unmasked by an inadequate cardiac response to hemodynamic stress, the diagnosis of cirrhotic cardiomyopathy is challenging and demands a multimodal approach. There is currently no specific therapy, but there are prognostically effective drugs available to treat heart failure. Therefore, it is crucial to identify patients with chronic liver disease and heart failure in order to ameliorate their outcome. This article attempts to highlight the most important aspects of cirrhotic cardiomyopathy and draws attention to this condition.
摘要：
肝硬化心肌病代表与晚期肝病相关的心脏功能障碍综合征。它是复杂的病理生理过程的结果，使疾病的进程复杂化，并且通常与不良预后相关。病理生理学，门脉高压是导致高动力循环的关键因素，通过神经体液轴的过度激活。肠梗阻,亚临床炎症和肝细胞功能不全，有几种血管活性介质的合成或代谢缺陷，是这个过程的重要组成部分。由于它通常在休息时不明显，并且仅因对血流动力学压力的心脏反应不足而掩盖，肝硬化心肌病的诊断具有挑战性,需要多模式诊断.目前还没有具体的治疗方法,但是有治疗心力衰竭的预后有效药物。因此,确定慢性肝病和心力衰竭患者对改善其预后至关重要.本文试图强调肝硬化心肌病的最重要方面，并提请注意这种情况。
