PDF(Pubmed)
Abstract：
UNASSIGNED: There have been numerous studies on NMDA receptors as therapeutic targets for depression. However, so far, there has been no comprehensive scientometric analysis of this field. Thus, we conducted a scientometric analysis with the aim of better elucidating the research hotspots and future trends in this field.
UNASSIGNED: Publications on NMDAR in Depression between 2004 and 2023 were retrieved from the Web of Science Core Collection (WoSCC) database. Then, VOSviewer, CiteSpace, Scimago Graphica, and R-bibliometrix-were used for the scientometric analysis and visualization.
UNASSIGNED: 5,092 qualified documents were identified to scientometric analysis. In the past 20 years, there has been an upward trend in the number of annual publications. The United States led the world in terms of international collaborations, publications, and citations. 15 main clusters were identified from the co-cited references analysis with notable modularity (Q-value = 0.7628) and silhouette scores (S-value = 0.9171). According to the keyword and co-cited references analysis, treatment-resistant depression ketamine (an NMDAR antagonist), oxidative stress, synaptic plasticity, neuroplasticity related downstream factors like brain-derived neurotrophic factor were the research hotspots in recent years.
UNASSIGNED: As the first scientometric analysis of NMDAR in Depression, this study shed light on the development, trends, and hotspots of research about NMDAR in Depression worldwide. The application and potential mechanisms of ketamine in the treatment of major depressive disorder (MDD) are still a hot research topic at present. However, the side effects of NMDAR antagonist like ketamine have prompted research on new rapid acting antidepressants.
UNASSIGNED: Publications on NMDAR in Depression between 2004 and 2023 were retrieved from the Web of Science Core Collection (WoSCC) database. Then, VOSviewer, CiteSpace, Scimago Graphica, and R-bibliometrix-were used for the scientometric analysis and visualization.
UNASSIGNED: 5,092 qualified documents were identified to scientometric analysis. In the past 20 years, there has been an upward trend in the number of annual publications. The United States led the world in terms of international collaborations, publications, and citations. 15 main clusters were identified from the co-cited references analysis with notable modularity (Q-value = 0.7628) and silhouette scores (S-value = 0.9171). According to the keyword and co-cited references analysis, treatment-resistant depression ketamine (an NMDAR antagonist), oxidative stress, synaptic plasticity, neuroplasticity related downstream factors like brain-derived neurotrophic factor were the research hotspots in recent years.
UNASSIGNED: As the first scientometric analysis of NMDAR in Depression, this study shed light on the development, trends, and hotspots of research about NMDAR in Depression worldwide. The application and potential mechanisms of ketamine in the treatment of major depressive disorder (MDD) are still a hot research topic at present. However, the side effects of NMDAR antagonist like ketamine have prompted research on new rapid acting antidepressants.
摘要：
■已经有许多关于NMDA受体作为抑郁症的治疗靶标的研究。然而,到目前为止,没有对这一领域进行全面的科学计量学分析。因此，我们进行了科学计量学分析，目的是更好地阐明该领域的研究热点和未来趋势。
■从WebofScienceCoreCollection（WoSCC）数据库检索了2004年至2023年抑郁症中有关NMDAR的出版物。然后，VOSviewer,CiteSpace,ScimagoGraphica,和R-bibliometrix-用于科学计量分析和可视化。
■5,092份合格文件被确定为进行科学计量分析。在过去的20年里,年度出版物数量呈上升趋势。美国在国际合作方面领先世界，出版物,和引用。从共同引用的参考文献分析中鉴定出15个主要簇，具有显着的模块化（Q值=0.7628）和轮廓得分（S值=0.9171）。根据关键词和共同引用的参考文献分析，治疗抗性抑郁症氯胺酮（NMDAR拮抗剂），氧化应激，突触可塑性，神经可塑性相关下游因子脑源性神经营养因子是近年来的研究热点。
■作为抑郁症中NMDAR的第一个科学计量学分析，这项研究揭示了发展，趋势,以及全球抑郁症NMDAR研究的热点。氯胺酮在重度抑郁障碍(MDD)治疗中的应用及潜在作用机制仍是目前研究的热点。然而,NMDAR拮抗剂如氯胺酮的副作用促使人们研究新的速效抗抑郁药.
■从WebofScienceCoreCollection（WoSCC）数据库检索了2004年至2023年抑郁症中有关NMDAR的出版物。然后，VOSviewer,CiteSpace,ScimagoGraphica,和R-bibliometrix-用于科学计量分析和可视化。
■5,092份合格文件被确定为进行科学计量分析。在过去的20年里,年度出版物数量呈上升趋势。美国在国际合作方面领先世界，出版物,和引用。从共同引用的参考文献分析中鉴定出15个主要簇，具有显着的模块化（Q值=0.7628）和轮廓得分（S值=0.9171）。根据关键词和共同引用的参考文献分析，治疗抗性抑郁症氯胺酮（NMDAR拮抗剂），氧化应激，突触可塑性，神经可塑性相关下游因子脑源性神经营养因子是近年来的研究热点。
■作为抑郁症中NMDAR的第一个科学计量学分析，这项研究揭示了发展，趋势,以及全球抑郁症NMDAR研究的热点。氯胺酮在重度抑郁障碍(MDD)治疗中的应用及潜在作用机制仍是目前研究的热点。然而,NMDAR拮抗剂如氯胺酮的副作用促使人们研究新的速效抗抑郁药.
