UNASSIGNED: Data for this cross-sectional study were collected between January 2014 and January 2022 at Wuhan Jinyintan Hospital. The ratio of inflammatory indicators, including Systemic Inflammatory Response Index (SIRI), C-reactive protein-to-lymphocyte ratio (CLR), eosinophil count-to-lymphocyte count ratio (ELR), were calculated. Univariate and multivariate logistic regression analyses were conducted to explore the association between the ratio of inflammatory indicators and TOPD. Furthermore, the relationship between the ratio of inflammatory indicators and TOPD was investigated using propensity score matching (PSM) and receiver operating characteristic (ROC) curve analysis was performed to evaluate their predictive value for TOPD.
UNASSIGNED: The present study included a total of 737 patients, of whom 83 participants (11.26%) had TOPD. Sixty-nine TOPD patients and 69 non-TOPD (NTOPD) patients were successfully matched. Univariate and multivariable logistics regression analysis, conducted before and after PSM, revealed that SIRI was independently significantly associated with an increased risk of TOPD. The area under curve (AUC) of SIRI were 0.702 and 0.668 before and after PSM, respectively. Additionally, patients were stratified into four different groups based on SIRI quartiles for further analysis. The prevalence of TOPD in TB patients showed an increase with higher SIRI values, both before and after PSM.
UNASSIGNED: Levels of inflammatory indicators were higher in TOPD patients when compared to NTOPD patients. SIRI may be a simple and useful inflammatory index for assessing TOPD, and TB patients with higher values of SIRI are more likely to be high-risk group for TOPD.
■本横断面研究的数据是2014年1月至2022年1月在武汉金银滩医院收集的。炎症指标的比率,包括全身炎症反应指数(SIRI),C反应蛋白与淋巴细胞比率(CLR),嗜酸性粒细胞计数与淋巴细胞计数比值(ELR),被计算。进行单因素和多因素logistic回归分析以探讨炎症指标比值与TOPD之间的关系。此外,采用倾向评分匹配(PSM)研究炎症指标比值与TOPD之间的关系,并进行受试者工作特征(ROC)曲线分析以评估其对TOPD的预测价值.
■本研究共纳入737名患者,其中83名参与者(11.26%)患有TOPD。69例TOPD患者和69例非TOPD(NTOPD)患者成功匹配。单变量和多变量物流回归分析,在PSM之前和之后进行,显示SIRI与TOPD风险增加独立显著相关.PSM前后SIRI曲线下面积(AUC)分别为0.702和0.668,分别。此外,我们根据SIRI四分位数将患者分为4组进行进一步分析.随着SIRI值的升高,结核病患者的TOPD患病率增加,在PSM之前和之后。
■与NTOPD患者相比,TOPD患者的炎症指标水平更高。SIRI可能是评估TOPD的简单有用的炎症指标,SIRI值较高的TB患者更有可能成为TOPD的高危人群。