PDF(Pubmed)
Abstract：
UNASSIGNED: Studying the relationship between strenuous sports or other exercises (SSOE) and lung cancer risk remains underexplored. Traditional observational studies face challenges like confounders and inverse causation. However, Mendelian randomization (MR) provides a promising approach in epidemiology and genetics, using genetic variants as instrumental variables to investigate causal relationships. By leveraging MR, we have scrutinized the causal link between SSOE and lung cancer development.
UNASSIGNED: Twelve single-nucleotide polymorphisms (SNPs) associated with SSOE, as identified in previously published genome-wide association studies, were utilized as instrumental variables in our investigation. Summary genetic data at the individual level were obtained from relevant studies and cancer consortia. The study encompassed a total of 11,348 cases and 15,861 controls. The statistical technique of inverse variance-weighting (IVW), commonly employed in meta-analyses and MR studies, was employed to assess the causal relationship between SSOE and lung cancer risk.
UNASSIGNED: The MR risk analysis indicated a causal relationship between SSOE and the incidence of lung cancer, with evidence of a reduced risk for overall lung cancer [odds ratio (OR) =0.129; 95% confidence interval (CI): 0.021-0.779; P=0.03], lung adenocarcinoma (OR =0.161; 95% CI: 0.012-2.102; P=0.16) and squamous cell lung cancer (OR =0.045; 95% CI: 0.003-0.677; P=0.03). The combined OR for lung cancer from SSOE (controlling for waist circumference and smoking status) was 0.054 (95% CI: 0.010-0.302, P<0.001).
UNASSIGNED: Our MR analysis findings indicate a potential correlation between SSOE and a protective effect against lung cancer development. Further investigation is imperative to uncover the precise mechanistic link between them.
UNASSIGNED: Twelve single-nucleotide polymorphisms (SNPs) associated with SSOE, as identified in previously published genome-wide association studies, were utilized as instrumental variables in our investigation. Summary genetic data at the individual level were obtained from relevant studies and cancer consortia. The study encompassed a total of 11,348 cases and 15,861 controls. The statistical technique of inverse variance-weighting (IVW), commonly employed in meta-analyses and MR studies, was employed to assess the causal relationship between SSOE and lung cancer risk.
UNASSIGNED: The MR risk analysis indicated a causal relationship between SSOE and the incidence of lung cancer, with evidence of a reduced risk for overall lung cancer [odds ratio (OR) =0.129; 95% confidence interval (CI): 0.021-0.779; P=0.03], lung adenocarcinoma (OR =0.161; 95% CI: 0.012-2.102; P=0.16) and squamous cell lung cancer (OR =0.045; 95% CI: 0.003-0.677; P=0.03). The combined OR for lung cancer from SSOE (controlling for waist circumference and smoking status) was 0.054 (95% CI: 0.010-0.302, P<0.001).
UNASSIGNED: Our MR analysis findings indicate a potential correlation between SSOE and a protective effect against lung cancer development. Further investigation is imperative to uncover the precise mechanistic link between them.
摘要：
■研究剧烈运动或其他运动（SSOE）与肺癌风险之间的关系仍未得到充分研究。传统的观察研究面临着混杂因素和反向因果关系等挑战。然而,孟德尔随机化（MR）在流行病学和遗传学方面提供了一种有前途的方法，使用遗传变异作为工具变量来研究因果关系。通过利用MR，我们仔细研究了SSOE与肺癌发生之间的因果关系.
■与SSOE相关的12个单核苷酸多态性（SNPs），正如先前发表的全基因组关联研究中所确定的那样，在我们的调查中被用作工具变量。从相关研究和癌症联盟获得个体水平的遗传数据摘要。该研究共涵盖11,348例病例和15,861例对照。方差反加权(IVW)的统计技术，常用于荟萃分析和MR研究，用于评估SSOE与肺癌风险之间的因果关系。
■MR风险分析表明SSOE与肺癌发病率之间存在因果关系，有证据表明总体肺癌风险降低[比值比（OR）=0.129;95％置信区间（CI）：0.021-0.779;P=0.03]，肺腺癌(OR=0.161;95%CI:0.012-2.102;P=0.16)和鳞状细胞肺癌(OR=0.045;95%CI:0.003-0.677;P=0.03)。SSOE对肺癌的综合OR（控制腰围和吸烟状态）为0.054（95％CI：0.010-0.302，P<0.001）。
■我们的MR分析结果表明SSOE与肺癌发展的保护作用之间存在潜在的相关性。必须进一步调查以发现它们之间的精确机械联系。
■与SSOE相关的12个单核苷酸多态性（SNPs），正如先前发表的全基因组关联研究中所确定的那样，在我们的调查中被用作工具变量。从相关研究和癌症联盟获得个体水平的遗传数据摘要。该研究共涵盖11,348例病例和15,861例对照。方差反加权(IVW)的统计技术，常用于荟萃分析和MR研究，用于评估SSOE与肺癌风险之间的因果关系。
■MR风险分析表明SSOE与肺癌发病率之间存在因果关系，有证据表明总体肺癌风险降低[比值比（OR）=0.129;95％置信区间（CI）：0.021-0.779;P=0.03]，肺腺癌(OR=0.161;95%CI:0.012-2.102;P=0.16)和鳞状细胞肺癌(OR=0.045;95%CI:0.003-0.677;P=0.03)。SSOE对肺癌的综合OR（控制腰围和吸烟状态）为0.054（95％CI：0.010-0.302，P<0.001）。
■我们的MR分析结果表明SSOE与肺癌发展的保护作用之间存在潜在的相关性。必须进一步调查以发现它们之间的精确机械联系。
