UNASSIGNED: Twelve single-nucleotide polymorphisms (SNPs) associated with SSOE, as identified in previously published genome-wide association studies, were utilized as instrumental variables in our investigation. Summary genetic data at the individual level were obtained from relevant studies and cancer consortia. The study encompassed a total of 11,348 cases and 15,861 controls. The statistical technique of inverse variance-weighting (IVW), commonly employed in meta-analyses and MR studies, was employed to assess the causal relationship between SSOE and lung cancer risk.
UNASSIGNED: The MR risk analysis indicated a causal relationship between SSOE and the incidence of lung cancer, with evidence of a reduced risk for overall lung cancer [odds ratio (OR) =0.129; 95% confidence interval (CI): 0.021-0.779; P=0.03], lung adenocarcinoma (OR =0.161; 95% CI: 0.012-2.102; P=0.16) and squamous cell lung cancer (OR =0.045; 95% CI: 0.003-0.677; P=0.03). The combined OR for lung cancer from SSOE (controlling for waist circumference and smoking status) was 0.054 (95% CI: 0.010-0.302, P<0.001).
UNASSIGNED: Our MR analysis findings indicate a potential correlation between SSOE and a protective effect against lung cancer development. Further investigation is imperative to uncover the precise mechanistic link between them.
■与SSOE相关的12个单核苷酸多态性(SNPs),正如先前发表的全基因组关联研究中所确定的那样,在我们的调查中被用作工具变量。从相关研究和癌症联盟获得个体水平的遗传数据摘要。该研究共涵盖11,348例病例和15,861例对照。方差反加权(IVW)的统计技术,常用于荟萃分析和MR研究,用于评估SSOE与肺癌风险之间的因果关系。
■MR风险分析表明SSOE与肺癌发病率之间存在因果关系,有证据表明总体肺癌风险降低[比值比(OR)=0.129;95%置信区间(CI):0.021-0.779;P=0.03],肺腺癌(OR=0.161;95%CI:0.012-2.102;P=0.16)和鳞状细胞肺癌(OR=0.045;95%CI:0.003-0.677;P=0.03)。SSOE对肺癌的综合OR(控制腰围和吸烟状态)为0.054(95%CI:0.010-0.302,P<0.001)。
■我们的MR分析结果表明SSOE与肺癌发展的保护作用之间存在潜在的相关性。必须进一步调查以发现它们之间的精确机械联系。