PDF(Pubmed)
Abstract：
UNASSIGNED: In patients with pulmonary nodules (PNs), computed tomography (CT)-guided localization is commonly performed prior to the resection of these nodules through video-assisted thoracic surgery (VATS).
UNASSIGNED: To evaluate the relative clinical efficacy of coil and anchored needle (AN) insertion as approaches to preoperative CT-guided PN localization.
UNASSIGNED: This single-center, prospective, open-label, randomized controlled trial (registration number: NCT05183945) enrolled consecutive patients from January 2022 to July 2022, assigning these patients at random to undergo either coil or AN localization prior to VATS. Efficacy and safety outcomes in these two groups were then compared.
UNASSIGNED: This study enrolled in total 100 patients with 120 PNs who were assigned at random to the coil (patients = 50; PNs = 60) and AN (patients = 50; PNs = 60) localization groups. The respective technical success rates for coil and AN localization were 98.3% (59/60) and 100% (60/60), with no significant difference between the groups (p = 1.000). The coil group had a significantly longer median duration of localization relative to the AN group (16.0 min vs. 8.0 min, p < 0.001). Similar rates of localization-related pneumothorax (8.3% vs. 5.0%, p = 0.715) and pulmonary hemorrhage (5.0% vs. 13.3%, p = 0.110) were observed in both groups. In addition, the VATS resection procedures achieved 100% technical success rates in both of these localization groups.
UNASSIGNED: Both coil- and AN-based localization approaches can be successfully employed to localize PNs prior to VATS resection, with the AN localization procedure requiring less time to complete on average as compared to the coil-based approach.
UNASSIGNED: To evaluate the relative clinical efficacy of coil and anchored needle (AN) insertion as approaches to preoperative CT-guided PN localization.
UNASSIGNED: This single-center, prospective, open-label, randomized controlled trial (registration number: NCT05183945) enrolled consecutive patients from January 2022 to July 2022, assigning these patients at random to undergo either coil or AN localization prior to VATS. Efficacy and safety outcomes in these two groups were then compared.
UNASSIGNED: This study enrolled in total 100 patients with 120 PNs who were assigned at random to the coil (patients = 50; PNs = 60) and AN (patients = 50; PNs = 60) localization groups. The respective technical success rates for coil and AN localization were 98.3% (59/60) and 100% (60/60), with no significant difference between the groups (p = 1.000). The coil group had a significantly longer median duration of localization relative to the AN group (16.0 min vs. 8.0 min, p < 0.001). Similar rates of localization-related pneumothorax (8.3% vs. 5.0%, p = 0.715) and pulmonary hemorrhage (5.0% vs. 13.3%, p = 0.110) were observed in both groups. In addition, the VATS resection procedures achieved 100% technical success rates in both of these localization groups.
UNASSIGNED: Both coil- and AN-based localization approaches can be successfully employed to localize PNs prior to VATS resection, with the AN localization procedure requiring less time to complete on average as compared to the coil-based approach.
摘要：
■在患有肺结节（PNs）的患者中，计算机断层扫描(CT)引导定位通常在通过电视胸腔镜手术(VATS)切除这些结节之前进行.
■评估线圈和锚定针（AN）插入作为术前CT引导的PN定位方法的相对临床疗效。
■这个单中心，prospective,开放标签，随机对照试验(注册号:NCT05183945)纳入了2022年1月至2022年7月的连续患者,随机分配这些患者在VATS之前进行线圈或AN定位.然后比较两组的疗效和安全性结果。
■本研究共纳入100名120名PNs患者，随机分为线圈组（患者=50；PNs=60）和AN组（患者=50；PNs=60）定位组。线圈和AN定位的技术成功率分别为98.3％（59/60）和100％（60/60），组间无显著差异(p=1.000)。相对于AN组，线圈组的定位中位持续时间明显更长（16.0minvs.8.0分钟,p<0.001)。与定位相关的气胸相似的发生率（8.3％vs.5.0%，p=0.715）和肺出血（5.0%vs.13.3%,p=0.110）在两组中均观察到。此外,在这两个定位组中,VATS切除手术的技术成功率均达到100%.
■基于线圈和AN的定位方法都可以成功地用于在VATS切除之前定位PN，与基于线圈的方法相比，AN定位过程平均需要更少的时间来完成。
■评估线圈和锚定针（AN）插入作为术前CT引导的PN定位方法的相对临床疗效。
■这个单中心，prospective,开放标签，随机对照试验(注册号:NCT05183945)纳入了2022年1月至2022年7月的连续患者,随机分配这些患者在VATS之前进行线圈或AN定位.然后比较两组的疗效和安全性结果。
■本研究共纳入100名120名PNs患者，随机分为线圈组（患者=50；PNs=60）和AN组（患者=50；PNs=60）定位组。线圈和AN定位的技术成功率分别为98.3％（59/60）和100％（60/60），组间无显著差异(p=1.000)。相对于AN组，线圈组的定位中位持续时间明显更长（16.0minvs.8.0分钟,p<0.001)。与定位相关的气胸相似的发生率（8.3％vs.5.0%，p=0.715）和肺出血（5.0%vs.13.3%,p=0.110）在两组中均观察到。此外,在这两个定位组中,VATS切除手术的技术成功率均达到100%.
■基于线圈和AN的定位方法都可以成功地用于在VATS切除之前定位PN，与基于线圈的方法相比，AN定位过程平均需要更少的时间来完成。
