Abstract：
Literature shows heterogeneous age-standardized dementia incidence rates across US Asian American, Native Hawaiian, and Pacific Islanders (AANHPI), but no estimates of population-representative dementia incidence exist due to lack of AANHPI longitudinal probability samples. We compared harmonized characteristics between AANHPI Kaiser Permanente Northern California members (KPNC cohort) and the target population of AANHPI 60+ with private or Medicare insurance using the California Health Interview Survey. We used stabilized inverse odds of selection weights (sIOSW) to estimate ethnicity-specific crude and age-standardized dementia incidence rates and cumulative risk by age 90 in the target population. Differences between the KPNC cohort and target population varied by ethnicity. sIOSW eliminated most differences in larger ethnic groups; some differences remained in smaller groups. Estimated crude dementia incidence rates using sIOSW (versus unweighted) were similar in Chinese, Filipinos, Pacific Islanders and Vietnamese, and higher in Japanese, Koreans, and South Asians. Unweighted and weighted age-standardized incidence rates differed for South Asians. Unweighted and weighted cumulative risk were similar for all groups. We estimated the first population-representative dementia incidence rates and cumulative risk in AANHPI ethnic groups. We encountered some estimation problems and weighted estimates were imprecise, highlighting challenges using weighting to extend inferences to target populations.
摘要：
文献显示，美国亚裔美国人的年龄标准化痴呆发病率不同，夏威夷原住民,和太平洋岛民（AANHPI），但由于缺乏AANHPI纵向概率样本,因此不存在对人群代表性痴呆发病率的估计.我们使用加利福尼亚州健康访谈调查比较了AANHPIKaiserPermanente北加州成员（KPNC队列）与AANHPI60+的目标人群之间的协调特征。我们使用稳定的选择权重倒数几率（sIOSW）来估计目标人群中种族特定的粗和年龄标准化的痴呆发病率以及90岁时的累积风险。KPNC队列和目标人群之间的差异因种族而异。sIOSW消除了较大种族群体的大多数差异；较小的群体仍然存在一些差异。使用sIOSW估计的粗痴呆发病率（与未加权）在中国相似，菲律宾人,太平洋岛民和越南人，日语更高，韩国人,南亚人。南亚人的未加权和加权年龄标准化发病率不同。所有组的未加权和加权累积风险相似。我们估计了AANHPI种族中第一个具有人口代表性的痴呆发病率和累积风险。我们遇到了一些估计问题，加权估计不精确，突出挑战，使用权重将推论扩展到目标人群。
