Abstract：
UNASSIGNED: Endometrial cancer (EC) has a high latency, making prognosis difficult to predict. Cancer antigen 125 (CA125) is not specific as a tumour marker for EC; however, complete blood count (CBC) inflammatory markers are associated with prognosis in various malignancies. Thus, this study investigated the value of CBC inflammatory markers combined with CA125 levels in predicting the prognosis of patients with EC.
UNASSIGNED: In this study, 517 patients with EC were recruited between January 2015 and January 2022, and clinical characteristics, CBC inflammatory markers, and CA125 levels were assessed. Differences in each index at different EC stages and the correlation between the index and EC stage were analysed, and the influence of the index on EC prognosis was evaluated.
UNASSIGNED: Platelet distribution width (PDW) levels were significantly lower in patients with advanced EC than in those with early EC, whereas the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and CA125 levels were significantly higher in patients with advanced EC (all P < 0.05). ROC curve and multivariate logistic regression analyses indicated that decreased PDW and increased CA125 levels were independent risk factors for EC staging progression. In addition, multivariate Cox regression analysis showed that the combination of low PDW and high CA125 (PDW + CA125 = 2) was an independent prognostic factor of survival in EC patients. Kaplan-Meier survival analysis indicated that patients with low PDW and high CA125 had worse overall survival.
UNASSIGNED: The PDW and CA125 score may be an independent prognostic factor for postoperative overall survival in patients with EC and a useful marker for predicting the prognosis of these patients.
Endometrial cancer (EC) has a high latency period, and the prognosis of EC is difficult to predict. The inflammatory response within the tumour microenvironment plays an important role in the occurrence and development of cancer. In our study, various inflammatory indicators in complete blood counts were comprehensively analysed, and cancer antigen 125 (CA125) was further used to predict the stage and prognosis of EC. The results showed that patients with low platelet distribution width (PDW) and high CA125 levels had poorer overall survival. The PDW and CA125 score may be used as a new independent prognostic indicator.
UNASSIGNED: In this study, 517 patients with EC were recruited between January 2015 and January 2022, and clinical characteristics, CBC inflammatory markers, and CA125 levels were assessed. Differences in each index at different EC stages and the correlation between the index and EC stage were analysed, and the influence of the index on EC prognosis was evaluated.
UNASSIGNED: Platelet distribution width (PDW) levels were significantly lower in patients with advanced EC than in those with early EC, whereas the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and CA125 levels were significantly higher in patients with advanced EC (all P < 0.05). ROC curve and multivariate logistic regression analyses indicated that decreased PDW and increased CA125 levels were independent risk factors for EC staging progression. In addition, multivariate Cox regression analysis showed that the combination of low PDW and high CA125 (PDW + CA125 = 2) was an independent prognostic factor of survival in EC patients. Kaplan-Meier survival analysis indicated that patients with low PDW and high CA125 had worse overall survival.
UNASSIGNED: The PDW and CA125 score may be an independent prognostic factor for postoperative overall survival in patients with EC and a useful marker for predicting the prognosis of these patients.
Endometrial cancer (EC) has a high latency period, and the prognosis of EC is difficult to predict. The inflammatory response within the tumour microenvironment plays an important role in the occurrence and development of cancer. In our study, various inflammatory indicators in complete blood counts were comprehensively analysed, and cancer antigen 125 (CA125) was further used to predict the stage and prognosis of EC. The results showed that patients with low platelet distribution width (PDW) and high CA125 levels had poorer overall survival. The PDW and CA125 score may be used as a new independent prognostic indicator.
摘要：
■子宫内膜癌（EC）具有很高的潜伏期，使预后难以预测。癌症抗原125（CA125）作为EC的肿瘤标志物不是特异性的；然而，全血细胞计数（CBC）炎症标志物与各种恶性肿瘤的预后相关。因此，本研究探讨了CBC炎性标志物联合CA125水平对EC患者预后的预测价值。
■在这项研究中，2015年1月至2022年1月招募了517例EC患者，CBC炎症标志物,和CA125水平进行评估。分析各指标在不同EC阶段的差异以及指标与EC阶段的相关性,评价指标对EC预后的影响。
■晚期EC患者的血小板分布宽度（PDW）水平明显低于早期EC患者，而全身免疫炎症指数(SII)，中性粒细胞与淋巴细胞比率（NLR），单核细胞与淋巴细胞比率（MLR），血小板与淋巴细胞比率（PLR），晚期EC患者CA125水平明显高于晚期EC患者(均P<0.05)。ROC曲线和多因素logistic回归分析显示PDW降低和CA125水平升高是EC分期进展的独立危险因素。此外,多因素Cox回归分析显示,低PDW和高CA125(PDW+CA125=2)是影响EC患者生存的独立预后因素。Kaplan-Meier生存分析显示，低PDW和高CA125患者的总生存率较差。
■PDW和CA125评分可能是EC患者术后总生存期的独立预后因素，也是预测这些患者预后的有用指标。
子宫内膜癌（EC）具有较高的潜伏期，EC的预后难以预测。肿瘤微环境内的炎症反应在癌症的发生和发展中起着重要作用。在我们的研究中,全面分析了全血细胞计数中的各种炎症指标，进一步用癌抗原125(CA125)预测EC的分期和预后。结果显示，低血小板分布宽度（PDW）和高CA125水平的患者总生存期较差。PDW和CA125评分可作为新的独立预后指标。
■在这项研究中，2015年1月至2022年1月招募了517例EC患者，CBC炎症标志物,和CA125水平进行评估。分析各指标在不同EC阶段的差异以及指标与EC阶段的相关性,评价指标对EC预后的影响。
■晚期EC患者的血小板分布宽度（PDW）水平明显低于早期EC患者，而全身免疫炎症指数(SII)，中性粒细胞与淋巴细胞比率（NLR），单核细胞与淋巴细胞比率（MLR），血小板与淋巴细胞比率（PLR），晚期EC患者CA125水平明显高于晚期EC患者(均P<0.05)。ROC曲线和多因素logistic回归分析显示PDW降低和CA125水平升高是EC分期进展的独立危险因素。此外,多因素Cox回归分析显示,低PDW和高CA125(PDW+CA125=2)是影响EC患者生存的独立预后因素。Kaplan-Meier生存分析显示，低PDW和高CA125患者的总生存率较差。
■PDW和CA125评分可能是EC患者术后总生存期的独立预后因素，也是预测这些患者预后的有用指标。
子宫内膜癌（EC）具有较高的潜伏期，EC的预后难以预测。肿瘤微环境内的炎症反应在癌症的发生和发展中起着重要作用。在我们的研究中,全面分析了全血细胞计数中的各种炎症指标，进一步用癌抗原125(CA125)预测EC的分期和预后。结果显示，低血小板分布宽度（PDW）和高CA125水平的患者总生存期较差。PDW和CA125评分可作为新的独立预后指标。
