PDF(Pubmed)
Abstract：
UNASSIGNED: Intestinal barrier dysfunction and systemic inflammation are common in obstructive sleep apnoea (OSA). We aimed to investigate the role of melatonin, an anti-inflammatory mediator, in mediating the relationships between OSA, intestinal barrier dysfunction and systemic inflammation.
UNASSIGNED: Two hundred and thirty-five male participants who complained with sleep problems and underwent whole night polysomnography at our sleep centre between 2017 and 2018 were enrolled. Polysomnographic data, anthropometric measurements and biochemical indicators were collected. Serum melatonin, intestinal barrier function biomarker zonula occludens-1 (ZO-1) and inflammatory biomarkers C-reactive protein (CRP) with lipopolysaccharide (LPS) were detected. Spearman\'s correlation analysis assessed the correlations between sleep parameters, melatonin and biomarkers (ZO-1, LPS and CRP). Mediation analysis explored the effect of OSA on intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
UNASSIGNED: As OSA severity increased, serum melatonin decreased, whereas ZO-1, LPS and CRP increased. Spearman\'s correlation analysis showed that serum melatonin was significantly negatively correlated with ZO-1 (r = -0.19, p < .05) and LPS (r = -0.20, p < .05) in the moderate-OSA group; serum melatonin was significantly negatively correlated with ZO-1 (r = -0.46, p < .01), LPS (r = -0.35, p < .01) and CPR (r = -0.30, p < .05) in the severe-OSA group. Mediation analyses showed melatonin explain 36.12% and 35.38% of the effect of apnoea-hypopnea index (AHI) on ZO-1 and LPS in moderate to severe OSA patients.
UNASSIGNED: Our study revealed that melatonin may be involved in mediating intestinal barrier dysfunction and systemic inflammation in moderate-to-severe OSA patients.
UNASSIGNED: Two hundred and thirty-five male participants who complained with sleep problems and underwent whole night polysomnography at our sleep centre between 2017 and 2018 were enrolled. Polysomnographic data, anthropometric measurements and biochemical indicators were collected. Serum melatonin, intestinal barrier function biomarker zonula occludens-1 (ZO-1) and inflammatory biomarkers C-reactive protein (CRP) with lipopolysaccharide (LPS) were detected. Spearman\'s correlation analysis assessed the correlations between sleep parameters, melatonin and biomarkers (ZO-1, LPS and CRP). Mediation analysis explored the effect of OSA on intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
UNASSIGNED: As OSA severity increased, serum melatonin decreased, whereas ZO-1, LPS and CRP increased. Spearman\'s correlation analysis showed that serum melatonin was significantly negatively correlated with ZO-1 (r = -0.19, p < .05) and LPS (r = -0.20, p < .05) in the moderate-OSA group; serum melatonin was significantly negatively correlated with ZO-1 (r = -0.46, p < .01), LPS (r = -0.35, p < .01) and CPR (r = -0.30, p < .05) in the severe-OSA group. Mediation analyses showed melatonin explain 36.12% and 35.38% of the effect of apnoea-hypopnea index (AHI) on ZO-1 and LPS in moderate to severe OSA patients.
UNASSIGNED: Our study revealed that melatonin may be involved in mediating intestinal barrier dysfunction and systemic inflammation in moderate-to-severe OSA patients.
摘要：
■肠屏障功能障碍和全身性炎症在阻塞性睡眠呼吸暂停（OSA）中很常见。我们的目的是研究褪黑素的作用，抗炎介质,在调解OSA之间的关系时，肠屏障功能障碍和全身性炎症。
■在2017年至2018年间在我们的睡眠中心抱怨睡眠问题并进行了整夜多导睡眠监测的230名男性参与者被招募。多导睡眠图数据,收集人体测量和生化指标。血清褪黑素，采用脂多糖(LPS)检测肠屏障功能生物标志物闭塞带-1(ZO-1)和炎性生物标志物C反应蛋白(CRP)。Spearman的相关分析评估了睡眠参数之间的相关性，褪黑素和生物标志物（ZO-1，LPS和CRP）。中介分析探讨OSA对中重度OSA患者肠屏障功能障碍及全身炎症反应的影响。
■随着OSA严重程度的增加，血清褪黑素降低，而ZO-1、LPS和CRP升高。Spearman相关分析显示,中度OSA组血清褪黑素与ZO-1(r=-0.19,p<.05)、LPS(r=-0.20,p<.05)呈显著负相关;血清褪黑素与ZO-1呈显著负相关(r=-0.46,p<.01)。重度OSA组的LPS(r=-0.35,p<.01)和CPR(r=-0.30,p<.05)。中介分析显示，褪黑素解释了中度至重度OSA患者中呼吸暂停低通气指数（AHI）对ZO-1和LPS的影响的36.12％和35.38％。
■我们的研究表明，褪黑素可能参与介导中度至重度OSA患者的肠屏障功能障碍和全身性炎症。
■在2017年至2018年间在我们的睡眠中心抱怨睡眠问题并进行了整夜多导睡眠监测的230名男性参与者被招募。多导睡眠图数据,收集人体测量和生化指标。血清褪黑素，采用脂多糖(LPS)检测肠屏障功能生物标志物闭塞带-1(ZO-1)和炎性生物标志物C反应蛋白(CRP)。Spearman的相关分析评估了睡眠参数之间的相关性，褪黑素和生物标志物（ZO-1，LPS和CRP）。中介分析探讨OSA对中重度OSA患者肠屏障功能障碍及全身炎症反应的影响。
■随着OSA严重程度的增加，血清褪黑素降低，而ZO-1、LPS和CRP升高。Spearman相关分析显示,中度OSA组血清褪黑素与ZO-1(r=-0.19,p<.05)、LPS(r=-0.20,p<.05)呈显著负相关;血清褪黑素与ZO-1呈显著负相关(r=-0.46,p<.01)。重度OSA组的LPS(r=-0.35,p<.01)和CPR(r=-0.30,p<.05)。中介分析显示，褪黑素解释了中度至重度OSA患者中呼吸暂停低通气指数（AHI）对ZO-1和LPS的影响的36.12％和35.38％。
■我们的研究表明，褪黑素可能参与介导中度至重度OSA患者的肠屏障功能障碍和全身性炎症。
