Abstract：
UNASSIGNED: Subclinical hypothyroidism (SCH) is a biochemical condition that is diagnosed when peripheral free thyroid hormone levels are within normal reference laboratory range but serum thyroid-stimulating hormone (TSH) levels are mildly elevated. The aim of this study was to investigate the relationship between SCH and arterial stiffness using two different non-invasive methods, including echocardiography and oscillometric arteriography.
UNASSIGNED: The study included 33 newly diagnosed SCH patients and 34 age- and gender-matched healthy controls. Systolic and diastolic diameters and elastic parameters of the aorta were calculated by 2D Transthoracic echocardiography (TTE). Central blood pressure and aortic stiffness values of patient groups were measured noninvasively from the brachial artery using Mobil-O-Graph arteriography. Pulse wave velocity (PWV) and augmentation index (AIx) were used as arterial stiffness indicators.
UNASSIGNED: There was no significant difference between SCH and control groups with regard to age, gender, and body mass index (BMI). Aortic strain and aortic distensibility, were significantly lower in the SCH group than in the control group (p < 0.001). PWV and AIx which measured by Mobil-O-Graph arteriography were found to be significantly higher in the subclinical hypothyroid group compared to the control group (p < 0.05).
UNASSIGNED: Aortic stiffness assessed by TTE and Mobil-O-Graph arteriography deteriorated in patients with SCH after excluding other cardiovascular risk factors. The assessment of aortic stiffness by the oscillometric method was easy and useful for widespread clinical use.
UNASSIGNED: The study included 33 newly diagnosed SCH patients and 34 age- and gender-matched healthy controls. Systolic and diastolic diameters and elastic parameters of the aorta were calculated by 2D Transthoracic echocardiography (TTE). Central blood pressure and aortic stiffness values of patient groups were measured noninvasively from the brachial artery using Mobil-O-Graph arteriography. Pulse wave velocity (PWV) and augmentation index (AIx) were used as arterial stiffness indicators.
UNASSIGNED: There was no significant difference between SCH and control groups with regard to age, gender, and body mass index (BMI). Aortic strain and aortic distensibility, were significantly lower in the SCH group than in the control group (p < 0.001). PWV and AIx which measured by Mobil-O-Graph arteriography were found to be significantly higher in the subclinical hypothyroid group compared to the control group (p < 0.05).
UNASSIGNED: Aortic stiffness assessed by TTE and Mobil-O-Graph arteriography deteriorated in patients with SCH after excluding other cardiovascular risk factors. The assessment of aortic stiffness by the oscillometric method was easy and useful for widespread clinical use.
摘要：
■亚临床甲状腺功能减退症（SCH）是一种生化疾病，当外周游离甲状腺激素水平在正常参考实验室范围内，但血清促甲状腺激素（TSH）水平轻度升高时被诊断出来。这项研究的目的是使用两种不同的非侵入性方法调查SCH和动脉僵硬度之间的关系，包括超声心动图和示波动脉造影。
■该研究包括33名新诊断的SCH患者和34名年龄和性别匹配的健康对照。通过二维经胸超声心动图（TTE）计算主动脉的收缩和舒张直径以及弹性参数。使用Mobil-O-Graph动脉造影从肱动脉无创测量患者组的中心血压和主动脉硬度值。脉搏波传导速度（PWV）和增强指数（AIx）作为动脉僵硬度指标。
■SCH组和对照组在年龄方面没有显着差异，性别,体重指数（BMI）。主动脉劳损和主动脉扩张性,SCH组明显低于对照组(p<0.001)。通过Mobil-O-Graph动脉造影测量的PWV和AIx在亚临床甲状腺功能减退组中发现明显高于对照组（p<0.05）。
■通过TTE和Mobil-O-Graphy动脉造影评估的SCH患者在排除其他心血管危险因素后，主动脉僵硬度恶化。通过示波法评估主动脉硬度容易且可用于广泛的临床应用。
■该研究包括33名新诊断的SCH患者和34名年龄和性别匹配的健康对照。通过二维经胸超声心动图（TTE）计算主动脉的收缩和舒张直径以及弹性参数。使用Mobil-O-Graph动脉造影从肱动脉无创测量患者组的中心血压和主动脉硬度值。脉搏波传导速度（PWV）和增强指数（AIx）作为动脉僵硬度指标。
■SCH组和对照组在年龄方面没有显着差异，性别,体重指数（BMI）。主动脉劳损和主动脉扩张性,SCH组明显低于对照组(p<0.001)。通过Mobil-O-Graph动脉造影测量的PWV和AIx在亚临床甲状腺功能减退组中发现明显高于对照组（p<0.05）。
■通过TTE和Mobil-O-Graphy动脉造影评估的SCH患者在排除其他心血管危险因素后，主动脉僵硬度恶化。通过示波法评估主动脉硬度容易且可用于广泛的临床应用。
