Abstract：
Nanocapsules enable multicomponent encapsulation of therapeutic cargoes with high encapsulation content and efficiency, which is vital for cancer immunotherapy. In the past, chemical crosslinking is used to synthesize nanocapsules, which can impede the regulatory approval process. Therefore, a new class of protein nanocapsules is developed by eliminating the need for chemical crosslinking by utilizing protein denaturation through a process that is referred to as \"baking at the droplet interface\". Such protein nanocapsules with antigens incorporated in the shell and a combination of encapsulated drugs showed an enhancement in the immune response of cells.
摘要：
纳米胶囊能够以高包封含量和效率实现治疗性货物的多组分包封，这对癌症免疫疗法至关重要。在过去,化学交联用于合成纳米胶囊，这可能会阻碍监管审批过程。因此,一种新的蛋白质纳米胶囊是通过利用蛋白质变性过程中的“在液滴界面烘烤”来消除对化学交联的需要而开发的。具有掺入壳中的抗原和包封的药物的组合的这种蛋白质纳米胶囊显示细胞的免疫应答的增强。
