Abstract：
Complementary and Alternative Medicine (CAM) is a therapeutic option currently used by autistic people with continued interest and uptake. There remains limited evidence regarding the efficacy of CAM use in autism. The aim of this systematic review is to comprehensively review published clinical trials to explore the efficacy of CAM in autism. A systematic literature review of available research published from June 2013 to March 2023 was conducted. Our literature search identified 1826 eligible citations, and duplications removed (n = 694) with 102 articles eligible for title/abstract screening. After full text review, 39 studies were included. The results of this systematic review identified that for autistic people, vitamin and mineral supplements may only be of benefit if there is a deficiency. The results also found that the main interventions used were dietary interventions and nutraceuticals, including targeted supplements, vitamins and minerals, omega 3 s and prebiotics, probiotics and digestive enzymes. The evidence does not support some of the most frequently utilised dietary interventions, such as a Gluten Free Casein Free (GFCF) diet, and the use of targeted nutraceutical supplements may be of benefit, but more conclusive research is still required to direct safe and effective treatment.
摘要：
补充和替代医学（CAM）是自闭症患者目前使用的一种治疗选择，具有持续的兴趣和吸收。关于在自闭症中使用CAM的功效的证据仍然有限。本系统综述的目的是全面回顾已发表的临床试验，以探讨CAM在自闭症中的疗效。对2013年6月至2023年3月发表的现有研究进行了系统的文献综述。我们的文献检索确定了1826篇合格的引文，并删除了重复（n=694），有102篇文章符合标题/摘要筛选条件。经过全文回顾,共纳入39项研究。这项系统评价的结果发现，对于自闭症患者来说，维生素和矿物质补充剂可能只有在缺乏时才有益。结果还发现，使用的主要干预措施是饮食干预和营养食品，包括有针对性的补充剂，维生素和矿物质,欧米茄3s和益生元，益生菌和消化酶。证据不支持一些最常用的饮食干预措施，例如无麸质无酪蛋白（GFCF）饮食，使用有针对性的营养补充剂可能会有好处，但仍需要更多的结论性研究来指导安全有效的治疗。
