PDF(Pubmed)
Abstract：
Caveolins are a family of transmembrane proteins located in caveolae, small lipid raft invaginations of the plasma membrane. The roles of caveolin-enriched lipid rafts are diverse, and include mechano-protection, lipid homeostasis, metabolism, transport, and cell signaling. Caveolin-1 (Cav-1) and other caveolins were described in endothelial cells and later in other cell types of the central nervous system (CNS), including neurons, astrocytes, oligodendrocytes, microglia, and pericytes. This pancellular presence of caveolins demands a better understanding of their functional roles in each cell type. In this review we describe the various functions of Cav-1 in the cells of normal and pathological brains. Several emerging preclinical findings suggest that Cav-1 could represent a potential therapeutic target in brain disorders.
摘要：
小窝蛋白是位于小窝中的跨膜蛋白家族，质膜的小脂筏内陷。富含小窝蛋白的脂筏的作用是多种多样的，包括机械保护，脂质稳态，新陈代谢，运输,和细胞信号。小窝蛋白-1（Cav-1）和其他小窝蛋白在内皮细胞中描述，后来在中枢神经系统（CNS）的其他细胞类型中描述，包括神经元，星形胶质细胞,少突胶质细胞,小胶质细胞,和周细胞.小窝蛋白的这种细胞存在需要更好地了解它们在每种细胞类型中的功能作用。在这篇综述中，我们描述了Cav-1在正常和病理大脑细胞中的各种功能。一些新兴的临床前发现表明，Cav-1可能是脑部疾病的潜在治疗靶标。
