Abstract：
BACKGROUND: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. BCCs occur mainly in exposed areas, such as the face and scalp. Therefore, surgical resection with narrow margins is highly desirable. However, narrow margins may increase the risk of positive histopathological margins. Outcomes for such treatment might be unfavorable, but evidence for such a conclusion is lacking.
METHODS: Between April 2015 and November 2023, a total of 230 Japanese cases with BCC which underwent surgical resection with 2-mm, 3-mm, or 5-mm margins were followed in our hospital. We conducted a retrospective review that focused on the recurrence rate and histopathological margins.
RESULTS: Recurrence was recorded if the follow-up time was longer than 3 months. One of the 198 cases (0.5%) developed a recurrence. The mean lateral and deep histopathological margins were 2,525.4 μm (30.8-14,034.6 μm) and 3,409 μm (199.9-16,523.6 μm), respectively. Recurrence rate was associated with tumor size and clinical tumor border. However, histopathological margin was not associated with recurrence rate, even when it was less than 1,000 μm.
CONCLUSIONS: A narrow histopathological margin is acceptable for surgical resection of BCC in Japanese patients.
METHODS: Between April 2015 and November 2023, a total of 230 Japanese cases with BCC which underwent surgical resection with 2-mm, 3-mm, or 5-mm margins were followed in our hospital. We conducted a retrospective review that focused on the recurrence rate and histopathological margins.
RESULTS: Recurrence was recorded if the follow-up time was longer than 3 months. One of the 198 cases (0.5%) developed a recurrence. The mean lateral and deep histopathological margins were 2,525.4 μm (30.8-14,034.6 μm) and 3,409 μm (199.9-16,523.6 μm), respectively. Recurrence rate was associated with tumor size and clinical tumor border. However, histopathological margin was not associated with recurrence rate, even when it was less than 1,000 μm.
CONCLUSIONS: A narrow histopathological margin is acceptable for surgical resection of BCC in Japanese patients.
摘要：
背景：基底细胞癌（BCC）是最常见的皮肤恶性肿瘤。BCC主要发生在暴露区域，例如面部和头皮。因此,手术切除与狭窄的边缘是非常可取的。然而,狭窄的边缘可能会增加组织病理学边缘阳性的风险.这种治疗的结果可能是不利的，但是缺乏这样一个结论的证据。
方法：在2015年4月至2023年11月之间，共有230例日本BCC患者接受了2毫米的手术切除，3-mm,或5毫米的边缘在我们医院随访。我们进行了回顾性审查，重点是复发率和组织病理学边缘。
结果：如果随访时间超过3个月，则记录复发。198例中有1例（0.5％）复发。平均横向和深层组织病理学边缘为2,525.4μm（30.8-14,034.6μm）和3,409μm（199.9-16,523.6μm），分别。复发率与肿瘤大小和临床肿瘤边界有关。然而,组织病理学边缘与复发率无关，甚至当它小于1000μm时。
结论：对于日本患者BCC的手术切除，狭窄的组织病理学切缘是可以接受的。
方法：在2015年4月至2023年11月之间，共有230例日本BCC患者接受了2毫米的手术切除，3-mm,或5毫米的边缘在我们医院随访。我们进行了回顾性审查，重点是复发率和组织病理学边缘。
结果：如果随访时间超过3个月，则记录复发。198例中有1例（0.5％）复发。平均横向和深层组织病理学边缘为2,525.4μm（30.8-14,034.6μm）和3,409μm（199.9-16,523.6μm），分别。复发率与肿瘤大小和临床肿瘤边界有关。然而,组织病理学边缘与复发率无关，甚至当它小于1000μm时。
结论：对于日本患者BCC的手术切除，狭窄的组织病理学切缘是可以接受的。
