Abstract：
BackgroundDementia is the leading cause of disability and imposes a significant burden on society. Previous studies have suggested an association between metabolites and cognitive decline. Although the metabolite composition differs between Western and Asian populations, studies targeting Asian populations remain scarce.MethodsThis cross-sectional study used data from a cohort survey of community-dwelling older adults aged ≥ 60 years living in Miyagi, Japan, conducted by Tohoku Medical Megabank Organization between 2013 and 2016. Forty-three metabolite variables quantified using nuclear magnetic resonance spectroscopy were used as explanatory variables. Dependent variable was the presence of cognitive decline (≤ 23 points), assessed by the Mini-Mental State Examination. Principal component (PC) analysis was performed to reduce the dimensionality of metabolite variables, followed by logistic regression analysis to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for cognitive decline.ResultsA total of 2,940 participants were included (men: 49.0%, mean age: 67.6 years). Among them, 1.9% showed cognitive decline. The first 12 PC components (PC1-PC12) accounted for 71.7% of the total variance. Multivariate analysis showed that PC1, which mainly represented essential amino acids, was associated with lower odds of cognitive decline (OR = 0.89; 95% CI, 0.80-0.98). PC2, which mainly included ketone bodies, was associated with cognitive decline (OR = 1.29; 95% CI, 1.11-1.51). PC3, which included amino acids, was associated with lower odds of cognitive decline (OR = 0.81; 95% CI, 0.66-0.99).ConclusionAmino acids are protectively associated with cognitive decline, whereas ketone metabolites are associated with higher odds of cognitive decline.
摘要：
背景痴呆症是导致残疾的主要原因，给社会带来了沉重负担。先前的研究表明代谢物与认知能力下降之间存在关联。尽管西方和亚洲人群的代谢物组成不同，针对亚洲人群的研究仍然很少。方法本横断面研究使用来自居住在宫城的60岁以上的社区居住老年人的队列调查数据，Japan,由东北医疗Megabank组织在2013年至2016年期间进行。使用核磁共振波谱定量的43个代谢物变量用作解释变量。因变量是存在认知能力下降(≤23分)，由迷你精神状态检查评估。进行主成分(PC)分析以降低代谢物变量的维数，然后进行logistic回归分析,计算认知功能下降的比值比(ORs)和95%置信区间(CIs).结果共纳入2,940名参与者(男性:49.0%,平均年龄：67.6岁）。其中,1.9%表现为认知能力下降。前12个PC组分(PC1-PC12)占总方差的71.7%。多变量分析表明，PC1主要代表必需氨基酸，与较低的认知下降几率相关(OR=0.89；95%CI，0.80-0.98)。PC2，主要包括酮体，与认知功能下降相关(OR=1.29;95%CI,1.11-1.51)。PC3，其中包括氨基酸，与较低的认知下降几率相关(OR=0.81；95%CI，0.66-0.99)。结论氨基酸与认知功能下降有保护作用,而酮代谢物与认知能力下降的几率较高相关。
