Abstract：
Electrical stimulation is emerging as a perioperative strategy to improve peripheral nerve regeneration and enhance functional recovery. Despite decades of research, new insights into the complex multifaceted mechanisms of electrical stimulation continue to emerge, providing greater understanding of the neurophysiology of nerve regeneration. In this study, we summarize what is known about how electrical stimulation modulates the molecular cascades and cellular responses innate to nerve injury and repair, and the consequential effects on axonal growth and plasticity. Further, we discuss how electrical stimulation is delivered in preclinical and clinical studies and identify knowledge gaps that may provide opportunities for optimization.
摘要：
电刺激正在成为改善周围神经再生和增强功能恢复的围手术期策略。尽管经过几十年的研究,对电刺激复杂的多方面机制的新见解不断涌现，提供对神经再生的神经生理学更深入的了解。在这项研究中,我们总结了已知的电刺激如何调节神经损伤和修复的分子级联和细胞反应，以及对轴突生长和可塑性的相应影响。Further,我们将讨论如何在临床前和临床研究中提供电刺激,并确定可能提供优化机会的知识差距.
