关键词: Axonal injury PEG-fusion Peripheral nerve injury Wallerian degeneration

Mesh : Humans Polyethylene Glycols / therapeutic use administration & dosage Peripheral Nerve Injuries / surgery Animals Nerve Regeneration

来  源:   DOI:10.1016/j.hcl.2024.05.001

Abstract:
Axons successfully repaired with polyethylene glycol (PEG) fusion tecnology restored axonal continuity thereby preventing their Wallerian degeneration and minimizing muscle atrophy. PEG fusion studies in animal models and preliminary clinical trials involving patients with digital nerve repair have shown promise for this therapeutic approach. PEG fusion is safe to perform, and given the enormous potential benefits, there is no reason not to explore its therapeutic potential.
摘要:
用聚乙二醇(PEG)融合技术成功修复的轴突恢复了轴突连续性,从而防止了它们的Wallerian变性并最大程度地减少了肌肉萎缩。动物模型中的PEG融合研究和涉及数字神经修复患者的初步临床试验显示了这种治疗方法的希望。PEG融合是安全的,考虑到巨大的潜在利益,没有理由不探索其治疗潜力。
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