IGF - 1 通过 Ras / PI3K / IKK / NF - κ B 信号通路抑制炎症并加速血管生成以促进伤口愈合。
关键词: Angiogenesis IGF-1 Inflammation Signaling pathways Wound healing
Mesh : Insulin-Like Growth Factor I / metabolism Animals Wound Healing / drug effects NF-kappa B / metabolism Signal Transduction / drug effects Inflammation / metabolism Phosphatidylinositol 3-Kinases / metabolism Humans Neovascularization, Physiologic / drug effects ras Proteins / metabolism Male I-kappa B Kinase / metabolism Cell Proliferation / drug effects Mice Mice, Inbred C57BL Human Umbilical Vein Endothelial Cells / drug effects Anti-Inflammatory Agents / pharmacology Endothelial Cells / drug effects metabolism Interferon-gamma / metabolism pharmacology Angiogenesis
来 源: DOI:10.1016/j.ejps.2024.106847