Abstract：
Treatment of Mycoplasma spp. pneumonia has rarely been described in domestic ferrets (Mustela putorius furo). A 10-month-old, 0.53 kg, female spayed domestic ferret was presented for oxygen-dependent, chronic dyspnea of one-month\'s duration. Physical examination findings included dyspnea, tachypnea, increased bronchovesicular sounds bilaterally, and an intermittent non-productive cough. Bloodwork abnormalities included a mild leukocytosis (8.6×103/µL), mild neutrophilia (4.0×103/µL), mild hypoalbuminemia (2.7 g/dL), mild hyperglobulinemia (3.3 g/dL), mild hyponatremia (147 mEq/L), and mild hypochloremia (111.4 mEq/L). Radiographs revealed a marked diffuse bronchial pattern with peribronchial cuffing, a mild main pulmonary artery bulge, distended caudal lobar pulmonary arteries, and decreased serosal detail within the abdomen. An echocardiogram revealed indications of moderate pulmonary hypertension and systolic anterior motion of the mitral valve. Polymerase chain reaction testing for Mycoplasma spp. was positive, and treatment was initiated with doxycycline (10 mg/kg PO q 12 h for 16 weeks), prednisolone (0.4 mg/kg PO q 12 h for 13 weeks, tapered to 0.2 mg/kg PO q 12 h for two weeks, then eventually increased to 0.7 mg/kg PO q 12 h until further notice), sildenafil (0.3 mg/kg PO q 24 h for 13 weeks), and oxygen supplementation via an oxygen cage for six weeks. On repeat echocardiogram eleven weeks after initiation of doxycycline therapy, the pulmonary hypertension had resolved. At follow up six months later, the ferret was stable on previously prescribed medications and did not require oxygen supplementation. Mycoplasma spp. and pulmonary hypertension should be considered in cases of respiratory distress in ferrets.
摘要：
支原体的治疗。在家养雪貂（Mustelaputoriusfuro）中很少描述肺炎。一个10个月大的孩子,0.53kg,雌性家养雪貂被认为是氧气依赖性的，持续一个月的慢性呼吸困难。体格检查结果包括呼吸困难，呼吸急促,双侧支气管囊泡声音增加，和间歇性非生产性咳嗽。血液异常包括轻度白细胞增多（8.6×103/微升），轻度中性粒细胞增多症（4.0×103/微升），轻度低蛋白血症（2.7g/dL），轻度高球蛋白血症（3.3g/dL），轻度低钠血症（147mEq/L），和轻度低氯血症（111.4mEq/L）。射线照片显示明显的弥漫性支气管模式，支气管周围袖套，轻度的主肺动脉隆起,扩张的尾叶肺动脉，腹部浆膜细节减少。超声心动图显示有中度肺动脉高压和二尖瓣收缩期前运动的迹象。支原体属的聚合酶链反应检测。是积极的，治疗开始使用多西环素（10mg/kgPOq12小时，持续16周），泼尼松龙（0.4mg/kgPOq12小时，持续13周，逐渐减少至0.2mg/kgPOq12小时，持续两周，然后最终增加到0.7mg/kgPOq12小时，直至另行通知)，西地那非（0.3mg/kgPOq24小时，共13周），通过氧笼补充氧气六周。在开始多西环素治疗后11周的重复超声心动图中，肺动脉高压已经解决。在六个月后的随访中，雪貂在之前的处方药下是稳定的,并且不需要补充氧气.支原体属。雪貂出现呼吸窘迫时，应考虑肺动脉高压。
