Abstract：
A geriatric Holland Lop rabbit presented for acute lameness. A pathologic fracture of the right distal femur associated with a pleomorphic rhabdomyosarcoma was diagnosed, and staging radiographs showed no overt metastasis upon initial presentation. The limb was amputated and submitted for microscopic examination. Immunohistochemical evaluation revealed the neoplastic cells were positive for desmin and MyoD1, and negative for cytokeratin AE1/AE3, CD204, IBA-1, and SMA. Gross, histologic, and immunohistochemical evaluation confirmed a diagnosis of pleomorphic rhabdomyosarcoma. The patient died 396 days after amputation, and a post-mortem examination showed metastatic sarcoma to multiple organs.
摘要：
一只老年荷兰罗布兔子因急性跛行而出现。诊断为右股骨远端病理性骨折并伴有多形性横纹肌肉瘤，和分期X线片显示首次出现时没有明显的转移。截肢并提交显微镜检查。免疫组织化学评估显示，肿瘤细胞的结蛋白和MyoD1阳性，而细胞角蛋白AE1/AE3，CD204，IBA-1和SMA阴性。Gross,组织学，免疫组织化学评估证实了多形性横纹肌肉瘤的诊断。病人在截肢后396天死亡,尸检显示多器官转移性肉瘤.
