Abstract：
BACKGROUND: Calciphylaxis patients historically have experienced diagnostic challenges and high morbidity; however limited data is available examining these characteristics over time.
OBJECTIVE: The primary goals were to a) investigate factors associated with diagnostic delay of calciphylaxis and b) assess morbidity outcomes. The secondary goal was to provide updated mortality rates.
METHODS: A retrospective review of 302 adult patients diagnosed with calciphylaxis between January 1, 2006 and December 31, 2022 was conducted. Univariate and multivariate statistical analyses were performed.
RESULTS: Nonnephrogenic calciphylaxis (P = .0004) and involvement of the fingers (P = .0001) were significantly associated with an increased diagnostic delay, whereas involvement of the arms (P = .01) and genitalia (P = .022) resulted in fewer days to diagnosis. Almost all patients with genitalia, finger, or toe involvement had nephrogenic disease. The number of complications per patient decreased with time, especially for wound infections (P = .028), increase in lesion number (P = .012), and recurrent hospitalizations (P = .020). Updated 1-year mortality rates were 36.70% and 30.77% for nephrogenic and nonnephrogenic calciphylaxis, respectively.
CONCLUSIONS: Limitations include the retrospective nature and data from a single institution.
CONCLUSIONS: Diagnostic delay, particularly in nonnephrogenic calciphylaxis, and complications per patient decreased with time, highlighting the importance of continued awareness to expedite diagnosis. Mortality rates have continued to improve in recent years.
OBJECTIVE: The primary goals were to a) investigate factors associated with diagnostic delay of calciphylaxis and b) assess morbidity outcomes. The secondary goal was to provide updated mortality rates.
METHODS: A retrospective review of 302 adult patients diagnosed with calciphylaxis between January 1, 2006 and December 31, 2022 was conducted. Univariate and multivariate statistical analyses were performed.
RESULTS: Nonnephrogenic calciphylaxis (P = .0004) and involvement of the fingers (P = .0001) were significantly associated with an increased diagnostic delay, whereas involvement of the arms (P = .01) and genitalia (P = .022) resulted in fewer days to diagnosis. Almost all patients with genitalia, finger, or toe involvement had nephrogenic disease. The number of complications per patient decreased with time, especially for wound infections (P = .028), increase in lesion number (P = .012), and recurrent hospitalizations (P = .020). Updated 1-year mortality rates were 36.70% and 30.77% for nephrogenic and nonnephrogenic calciphylaxis, respectively.
CONCLUSIONS: Limitations include the retrospective nature and data from a single institution.
CONCLUSIONS: Diagnostic delay, particularly in nonnephrogenic calciphylaxis, and complications per patient decreased with time, highlighting the importance of continued awareness to expedite diagnosis. Mortality rates have continued to improve in recent years.
摘要：
背景：从历史上看，钙中毒患者经历过诊断挑战和高发病率，然而，随着时间的推移，有限的数据可用于检查这些特征。
目的：主要目标是a）调查与钙化延迟诊断相关的因素和b）评估发病率结果。次要目标是提供最新的死亡率。
方法：对2006年1月1日至2022年12月31日诊断为钙化的302例成年患者进行回顾性分析。进行单变量和多变量统计分析。
结果：非肾源性钙化（p=0.0004）和手指受累（p=0.0001）与诊断延迟增加显著相关，而手臂（p=0.01）和生殖器（p=0.022）的受累导致诊断天数减少。几乎所有生殖器患者,手指,或脚趾受累有肾源性疾病。每位患者的并发症数量随着时间的推移而减少，尤其是伤口感染（p=0.028），病变数量增加（p=0.012），和反复住院（p=0.020）。更新后的1年死亡率分别为36.70％和30.77％的肾性和非肾性钙化，分别。
结论：限制包括回顾性性质和来自单一机构的数据。
结论：诊断延迟，特别是在非肾源性钙化中，每位患者的并发症随着时间的推移而减少，强调持续意识对加快诊断的重要性。近年来死亡率持续改善。
目的：主要目标是a）调查与钙化延迟诊断相关的因素和b）评估发病率结果。次要目标是提供最新的死亡率。
方法：对2006年1月1日至2022年12月31日诊断为钙化的302例成年患者进行回顾性分析。进行单变量和多变量统计分析。
结果：非肾源性钙化（p=0.0004）和手指受累（p=0.0001）与诊断延迟增加显著相关，而手臂（p=0.01）和生殖器（p=0.022）的受累导致诊断天数减少。几乎所有生殖器患者,手指,或脚趾受累有肾源性疾病。每位患者的并发症数量随着时间的推移而减少，尤其是伤口感染（p=0.028），病变数量增加（p=0.012），和反复住院（p=0.020）。更新后的1年死亡率分别为36.70％和30.77％的肾性和非肾性钙化，分别。
结论：限制包括回顾性性质和来自单一机构的数据。
结论：诊断延迟，特别是在非肾源性钙化中，每位患者的并发症随着时间的推移而减少，强调持续意识对加快诊断的重要性。近年来死亡率持续改善。
