PDF(Pubmed)
Abstract：
OBJECTIVE: The new corona virus infection, has a wide range of clinical manifestations. Fever and cough are the most common symptoms. The olfactory function may be also affected with COVID-19. In this randomized clinical trial, we wanted to evaluate the therapeutic effect of olfactory training with and without oral vitamin A for COVID-19-related olfactory dysfunction.
METHODS: Patients answered to the standard Persian version of anosmia reporting tool and performed the quick smell test before and after 12 weeks and at the end of the 12 months follow up. The patients were randomly allocated to three groups; Group A treatment with olfactory training, Group B treatment with oral vitamin A and olfactory training, and Group C as control group which only underwent nasal irrigation twice a day. Patients were treated for 3 months and followed up for 12 months.
RESULTS: Totally 90 patients were included in three groups. After interventions, 76.9% of patients in Group A, 86.7% of patients in Group B, and 26.7% of patients in Group C completely improved. The average intervention time was statistically significant in relationship with the final olfactory status of the patients in the 12 months follow-up. The olfactory training has significantly improved the smell alteration at the end of 3- and 12- months follow-up in A and B groups.
CONCLUSIONS: A three-months olfactory training is effective for improvement of COVID-19-related olfactory dysfunction. Adding daily oral vitamin A to olfactory training did not lead to better results in improving olfactory dysfunction.
METHODS: Step 2 (Level 2*): Randomized trial.
METHODS: Patients answered to the standard Persian version of anosmia reporting tool and performed the quick smell test before and after 12 weeks and at the end of the 12 months follow up. The patients were randomly allocated to three groups; Group A treatment with olfactory training, Group B treatment with oral vitamin A and olfactory training, and Group C as control group which only underwent nasal irrigation twice a day. Patients were treated for 3 months and followed up for 12 months.
RESULTS: Totally 90 patients were included in three groups. After interventions, 76.9% of patients in Group A, 86.7% of patients in Group B, and 26.7% of patients in Group C completely improved. The average intervention time was statistically significant in relationship with the final olfactory status of the patients in the 12 months follow-up. The olfactory training has significantly improved the smell alteration at the end of 3- and 12- months follow-up in A and B groups.
CONCLUSIONS: A three-months olfactory training is effective for improvement of COVID-19-related olfactory dysfunction. Adding daily oral vitamin A to olfactory training did not lead to better results in improving olfactory dysfunction.
METHODS: Step 2 (Level 2*): Randomized trial.
摘要：
目的：新型冠状病毒感染，具有广泛的临床表现。发烧和咳嗽是最常见的症状。COVID-19也可能影响嗅觉功能。在这项随机临床试验中，我们希望评估有无口服维生素A的嗅觉训练对COVID-19相关嗅觉功能障碍的治疗效果.
方法：患者回答标准波斯语版本的失语症报告工具，并在12周之前和之后以及12个月随访结束时进行快速嗅觉测试。将患者随机分为三组;A组采用嗅觉训练,B组治疗采用口服维生素A和嗅觉训练,C组为对照组，每天仅进行两次鼻腔冲洗。患者治疗3个月,随访12个月。
结果：共90例患者分为三组。干预后,A组76.9%的患者,B组86.7%的患者,C组26.7%的患者完全好转。平均干预时间与随访12个月患者最终嗅觉状态的关系有统计学意义。嗅觉训练显著改善了A组和B组3个月和12个月随访结束时的嗅觉改变。
结论：3个月的嗅觉训练可有效改善COVID-19相关的嗅觉功能障碍。在嗅觉训练中添加每日口服维生素A并不能改善嗅觉功能障碍。
方法：步骤2（级别2*）：随机试验。
方法：患者回答标准波斯语版本的失语症报告工具，并在12周之前和之后以及12个月随访结束时进行快速嗅觉测试。将患者随机分为三组;A组采用嗅觉训练,B组治疗采用口服维生素A和嗅觉训练,C组为对照组，每天仅进行两次鼻腔冲洗。患者治疗3个月,随访12个月。
结果：共90例患者分为三组。干预后,A组76.9%的患者,B组86.7%的患者,C组26.7%的患者完全好转。平均干预时间与随访12个月患者最终嗅觉状态的关系有统计学意义。嗅觉训练显著改善了A组和B组3个月和12个月随访结束时的嗅觉改变。
结论：3个月的嗅觉训练可有效改善COVID-19相关的嗅觉功能障碍。在嗅觉训练中添加每日口服维生素A并不能改善嗅觉功能障碍。
方法：步骤2（级别2*）：随机试验。
