Abstract：
Leptospirosis (LTPS) is a bacterial infection that affects humans, often with mild or no symptoms. It is estimated that approximately 10 % of patients with LTPS may experience multi-organ dysfunction, including renal abnormalities. In regions where LTPS is widespread, a considerable number of instances involving acute kidney injury (AKI) and chronic kidney disease (CKD) of unknown etiology (CKDu) have been reported. Additionally, studies have shown a correlation between kidney graft dysfunction in patients with stable kidney transplants after LTPS. These findings indicate that exposure to LTPS may increase the likelihood of kidney transplantation due to the onset of both acute and chronic kidney injuries. Simultaneously, it poses a potential risk to the stability of kidney grafts. Unfortunately, there is limited scientific literature addressing this issue, making it difficult to determine the negative impact that LTPS may have, such as its role as a risk factor for the need of kidney transplantation or as a threat to individuals who have undergone kidney transplants. This study aims to shed light on the immune mechanisms triggered during LTPS infection and their importance in both kidney damage and allograft dysfunction.
摘要：
钩端螺旋体病（LTPS）是一种影响人类的细菌感染，通常有轻微或没有症状。据估计，大约10％的LTPS患者可能会出现多器官功能障碍，包括肾脏异常.在LTPS普遍存在的地区，已经报道了相当多的涉及急性肾损伤(AKI)和病因不明的慢性肾脏病(CKD)的病例.此外,研究表明，LTPS后稳定肾移植患者的肾移植功能障碍之间存在相关性。这些发现表明，由于急性和慢性肾损伤的发作，暴露于LTPS可能会增加肾移植的可能性。同时,它对肾移植物的稳定性构成潜在风险。不幸的是,解决这个问题的科学文献有限，这使得很难确定LTPS可能产生的负面影响，例如，它作为需要肾移植的危险因素或对接受肾移植的个体构成威胁。这项研究旨在阐明LTPS感染期间触发的免疫机制及其在肾脏损伤和同种异体移植功能障碍中的重要性。
