Abstract：
BACKGROUND: Initiation of feeding after percutaneous endoscopic gastrostomy (PEG) placement has been debated. Randomized controlled trials (RCTs) have been performed on early feeding compared with delayed feeding after PEG placement with varying results. Therefore, a meta-analysis was conducted examining early vs delayed feeding after placement of a PEG.
METHODS: A comprehensive search of databases was conducted in January 2024. Peer-reviewed published RCTs comparing early feeding (≤4 h) with delayed feeding (>4 h) were identified and included in the meta-analysis. Meta-analysis was completed using pooled estimates of overall complications, individual complications, mortality ≤72 h, and number of day 1 significant gastric residual volumes.
RESULTS: Six RCTs (n = 467) were included in the analysis. Comparison of early feeding with delayed feeding after PEG showed no statistically significant differences for overall complications (P = 0.18), mortality ≤72 h (P = 0.3), and number of day 1 significant gastric residual volumes (P = 0.05). No differences were also noted for individual complications, including vomiting, wound infection, bleeding, or diarrhea.
CONCLUSIONS: Feeding ≤4 h after PEG have no differences in minor and major complications compared with that of delayed feeding. Early feeding ≤4 h is safe and should be recommended in future guidelines.
METHODS: A comprehensive search of databases was conducted in January 2024. Peer-reviewed published RCTs comparing early feeding (≤4 h) with delayed feeding (>4 h) were identified and included in the meta-analysis. Meta-analysis was completed using pooled estimates of overall complications, individual complications, mortality ≤72 h, and number of day 1 significant gastric residual volumes.
RESULTS: Six RCTs (n = 467) were included in the analysis. Comparison of early feeding with delayed feeding after PEG showed no statistically significant differences for overall complications (P = 0.18), mortality ≤72 h (P = 0.3), and number of day 1 significant gastric residual volumes (P = 0.05). No differences were also noted for individual complications, including vomiting, wound infection, bleeding, or diarrhea.
CONCLUSIONS: Feeding ≤4 h after PEG have no differences in minor and major complications compared with that of delayed feeding. Early feeding ≤4 h is safe and should be recommended in future guidelines.
摘要：
背景：经皮内镜胃造口术（PEG）放置后开始进食一直存在争议。与PEG放置后的延迟喂养相比，早期喂养进行了随机对照试验（RCT），结果不同。因此,我们进行了一项荟萃分析,检查了放置PEG后的早期喂养和延迟喂养.
方法：2024年1月对数据库进行了全面检索。同行评审发表的RCT比较早期喂养（≤4h）和延迟喂养（>4h）被确定并包括在荟萃分析中。使用总体并发症的汇总估计完成荟萃分析，个别并发症，死亡率≤72小时，和第1天的数量显著的胃残留量。
结果：六个随机对照试验（n=467）纳入分析。PEG后早期喂养与延迟喂养的比较显示总体并发症无统计学差异（P=0.18）。死亡率≤72小时(P=0.3)，第1天有显著的胃残留量(P=0.05)。个体并发症也没有差异，包括呕吐,伤口感染,出血,或腹泻。
结论：PEG后≤4小时喂养与延迟喂养相比，轻微和主要并发症没有差异。早期喂养≤4小时是安全的，应在未来的指南中推荐。
方法：2024年1月对数据库进行了全面检索。同行评审发表的RCT比较早期喂养（≤4h）和延迟喂养（>4h）被确定并包括在荟萃分析中。使用总体并发症的汇总估计完成荟萃分析，个别并发症，死亡率≤72小时，和第1天的数量显著的胃残留量。
结果：六个随机对照试验（n=467）纳入分析。PEG后早期喂养与延迟喂养的比较显示总体并发症无统计学差异（P=0.18）。死亡率≤72小时(P=0.3)，第1天有显著的胃残留量(P=0.05)。个体并发症也没有差异，包括呕吐,伤口感染,出血,或腹泻。
结论：PEG后≤4小时喂养与延迟喂养相比，轻微和主要并发症没有差异。早期喂养≤4小时是安全的，应在未来的指南中推荐。
