METHODS: A comprehensive search of databases was conducted in January 2024. Peer-reviewed published RCTs comparing early feeding (≤4 h) with delayed feeding (>4 h) were identified and included in the meta-analysis. Meta-analysis was completed using pooled estimates of overall complications, individual complications, mortality ≤72 h, and number of day 1 significant gastric residual volumes.
RESULTS: Six RCTs (n = 467) were included in the analysis. Comparison of early feeding with delayed feeding after PEG showed no statistically significant differences for overall complications (P = 0.18), mortality ≤72 h (P = 0.3), and number of day 1 significant gastric residual volumes (P = 0.05). No differences were also noted for individual complications, including vomiting, wound infection, bleeding, or diarrhea.
CONCLUSIONS: Feeding ≤4 h after PEG have no differences in minor and major complications compared with that of delayed feeding. Early feeding ≤4 h is safe and should be recommended in future guidelines.
方法:2024年1月对数据库进行了全面检索。同行评审发表的RCT比较早期喂养(≤4h)和延迟喂养(>4h)被确定并包括在荟萃分析中。使用总体并发症的汇总估计完成荟萃分析,个别并发症,死亡率≤72小时,和第1天的数量显著的胃残留量。
结果:六个随机对照试验(n=467)纳入分析。PEG后早期喂养与延迟喂养的比较显示总体并发症无统计学差异(P=0.18)。死亡率≤72小时(P=0.3),第1天有显著的胃残留量(P=0.05)。个体并发症也没有差异,包括呕吐,伤口感染,出血,或腹泻。
结论:PEG后≤4小时喂养与延迟喂养相比,轻微和主要并发症没有差异。早期喂养≤4小时是安全的,应在未来的指南中推荐。