Abstract：
Telangiectatic osteosarcoma (TOS) is a rare variant of osteosarcoma that typically affects young individuals and long bones. The case under discussion was seen in the mandible of a 57-year-old female and had rapidly grown in size within a week. Microscopically, the tumour was characterised by large vascular cavities surrounded by anaplastic cells. Thin lacy tumour osteoid was observed at various foci. Abundant multinucleated osteoclastic giant cells along with areas of necrosis were also noted. The tumour cells were positive for SATB2, while negative for Cytokeratin AE1/3, CD 34. Ki-67 positivity was observed in more than 50% of tumour cells. A diagnosis of high grade telangiectatic osteosarcoma was thus made.
摘要：
毛细血管扩张骨肉瘤（TOS）是骨肉瘤的一种罕见变体，通常会影响年轻人和长骨。正在讨论的病例出现在一名57岁女性的下颌骨中，并在一周内迅速增长。微观上,肿瘤的特征是被间变性细胞包围的大血管腔。在各个病灶均观察到了薄型花边肿瘤骨样。还注意到丰富的多核破骨细胞巨细胞以及坏死区域。肿瘤细胞SATB2阳性,而细胞角蛋白AE1/3、CD34阴性。在超过50%的肿瘤细胞中观察到Ki-67阳性。因此诊断为高度毛细血管扩张骨肉瘤。
