Abstract：
Down syndrome is the most frequently occurring genetic condition, with a substantial escalation in risk associated with advanced maternal age. The syndrome is characterized by a diverse range of phenotypes, affecting to some extent all levels of organization, and its progeroid nature - early manifestation of aspects of the senile phenotype. Despite extensive investigations, many aspects and mechanisms of the disease remain unexplored. The current review aims to provide an overview of the main causes and manifestations of Down syndrome, while also examining the phenomenon of accelerated aging and exploring potential therapeutic strategies.
摘要：
唐氏综合症是最常见的遗传病，与高龄产妇相关的风险大幅上升。该综合征的特征是不同的表型，在某种程度上影响了各级组织，及其孕激素性质-老年表型方面的早期表现。尽管进行了广泛的调查，该疾病的许多方面和机制仍未被探索。本综述旨在概述唐氏综合症的主要病因和表现,同时研究加速衰老的现象并探索潜在的治疗策略。
