PDF(Pubmed)
Abstract：
BACKGROUND: Cardiovascular magnetic resonance (CMR) is increasingly utilized to evaluate expanding cardiovascular conditions. The Society for Cardiovascular Magnetic Resonance (SCMR) Registry is a central repository for real-world clinical data to support cardiovascular research, including those relating to outcomes, quality improvement, and machine learning. The SCMR Registry is built on a regulatory-compliant, cloud-based infrastructure that houses searchable content and Digital Imaging and Communications in Medicine images. The goal of this study is to summarize the status of the SCMR Registry at 150,000 exams.
METHODS: The processes for data security, data submission, and research access are outlined. We interrogated the Registry and presented a summary of its contents.
RESULTS: Data were compiled from 154,458 CMR scans across 20 United States sites, containing 299,622,066 total images (∼100 terabytes of storage). Across reported values, the human subjects had an average age of 58 years (range 1 month to >90 years old), were 44% (63,070/145,275) female, 72% (69,766/98,008) Caucasian, and had a mortality rate of 8% (9,962/132,979). The most common indication was cardiomyopathy (35,369/131,581, 27%), and most frequently used current procedural terminology code was 75561 (57,195/162,901, 35%). Macrocyclic gadolinium-based contrast agents represented 89% (83,089/93,884) of contrast utilization after 2015. Short-axis cines were performed in 99% (76,859/77,871) of tagged scans, short-axis late gadolinium enhancement (LGE) in 66% (51,591/77,871), and stress perfusion sequences in 30% (23,241/77,871). Mortality data demonstrated increased mortality in patients with left ventricular ejection fraction <35%, the presence of wall motion abnormalities, stress perfusion defects, and infarct LGE, compared to those without these markers. There were 456,678 patient-years of all-cause mortality follow-up, with a median follow-up time of 3.6 years.
CONCLUSIONS: The vision of the SCMR Registry is to promote evidence-based utilization of CMR through a collaborative effort by providing a web mechanism for centers to securely upload de-identified data and images for research, education, and quality control. The Registry quantifies changing practice over time and supports large-scale real-world multicenter observational studies of prognostic utility.
METHODS: The processes for data security, data submission, and research access are outlined. We interrogated the Registry and presented a summary of its contents.
RESULTS: Data were compiled from 154,458 CMR scans across 20 United States sites, containing 299,622,066 total images (∼100 terabytes of storage). Across reported values, the human subjects had an average age of 58 years (range 1 month to >90 years old), were 44% (63,070/145,275) female, 72% (69,766/98,008) Caucasian, and had a mortality rate of 8% (9,962/132,979). The most common indication was cardiomyopathy (35,369/131,581, 27%), and most frequently used current procedural terminology code was 75561 (57,195/162,901, 35%). Macrocyclic gadolinium-based contrast agents represented 89% (83,089/93,884) of contrast utilization after 2015. Short-axis cines were performed in 99% (76,859/77,871) of tagged scans, short-axis late gadolinium enhancement (LGE) in 66% (51,591/77,871), and stress perfusion sequences in 30% (23,241/77,871). Mortality data demonstrated increased mortality in patients with left ventricular ejection fraction <35%, the presence of wall motion abnormalities, stress perfusion defects, and infarct LGE, compared to those without these markers. There were 456,678 patient-years of all-cause mortality follow-up, with a median follow-up time of 3.6 years.
CONCLUSIONS: The vision of the SCMR Registry is to promote evidence-based utilization of CMR through a collaborative effort by providing a web mechanism for centers to securely upload de-identified data and images for research, education, and quality control. The Registry quantifies changing practice over time and supports large-scale real-world multicenter observational studies of prognostic utility.
摘要：
目的：总结150,000次检查的SCMR注册状态。
背景：心血管磁共振（CMR）越来越多地用于评估不断扩大的心血管疾病。SCMRRegistry是支持心血管研究的现实世界临床数据的中央存储库。包括与结果有关的那些，质量改进,和机器学习。SCMR注册表建立在符合法规的基础上，基于云的基础设施，可容纳可搜索的内容以及医学数字成像和通信（DICOM）图像。
方法：数据安全的过程，数据提交，并概述了研究访问。我们询问了书记官处，并提供了其内容摘要。
结果：数据来自美国20个站点的154,458次CMR扫描，包含299,622,066张总图像（约100TB的存储空间）。人类受试者的平均年龄为58岁（范围为1个月至>90岁），44%是女性,72%白种人,死亡率为8%。最常见的适应症是心肌病（27%），最常用的当前程序术语(CPT)代码为75561(35%).2015年后，基于大环钆的造影剂占造影剂利用率的89%。在99%的扫描中进行了短轴扫描，短轴LGE在66%，和30%的应力灌注序列。死亡率数据显示左心室射血分数（LVEF）<35％的患者死亡率增加，壁运动异常的存在，应力灌注缺陷，和梗塞晚期钆增强（LGE），与没有这些标记的人相比。有456,678个患者年的全因死亡率随访，中位随访时间为3.6年。
结论：SCMRRegistry的愿景是通过协作努力，通过为中心提供一种网络机制，安全地上传去识别的数据和图像进行研究，促进CMR的循证利用。教育,和质量控制。注册表量化随时间变化的实践，并支持对预后效用的大规模现实世界多中心观察研究。
结论：SCMRRegistry是一个符合监管标准的基于云的中央存储库，用于多中心心血管研究的真实世界临床数据和DICOM图像。包括基于结果的数据。该注册表包含299,622,066个DICOM图像和456,678个患者年随访。来自美国20个地点的154,458次CMR扫描的数据显示，2015年后，心肌病是最常见的适应症，大环钆造影剂利用率为89%。总死亡率为8%，LVEF<35%的患者发病率较高，异常壁运动,缺血存在，或梗塞部位。登记处旨在通过合作努力促进基于证据的CMR利用，以积极影响心血管结果。
背景：心血管磁共振（CMR）越来越多地用于评估不断扩大的心血管疾病。SCMRRegistry是支持心血管研究的现实世界临床数据的中央存储库。包括与结果有关的那些，质量改进,和机器学习。SCMR注册表建立在符合法规的基础上，基于云的基础设施，可容纳可搜索的内容以及医学数字成像和通信（DICOM）图像。
方法：数据安全的过程，数据提交，并概述了研究访问。我们询问了书记官处，并提供了其内容摘要。
结果：数据来自美国20个站点的154,458次CMR扫描，包含299,622,066张总图像（约100TB的存储空间）。人类受试者的平均年龄为58岁（范围为1个月至>90岁），44%是女性,72%白种人,死亡率为8%。最常见的适应症是心肌病（27%），最常用的当前程序术语(CPT)代码为75561(35%).2015年后，基于大环钆的造影剂占造影剂利用率的89%。在99%的扫描中进行了短轴扫描，短轴LGE在66%，和30%的应力灌注序列。死亡率数据显示左心室射血分数（LVEF）<35％的患者死亡率增加，壁运动异常的存在，应力灌注缺陷，和梗塞晚期钆增强（LGE），与没有这些标记的人相比。有456,678个患者年的全因死亡率随访，中位随访时间为3.6年。
结论：SCMRRegistry的愿景是通过协作努力，通过为中心提供一种网络机制，安全地上传去识别的数据和图像进行研究，促进CMR的循证利用。教育,和质量控制。注册表量化随时间变化的实践，并支持对预后效用的大规模现实世界多中心观察研究。
结论：SCMRRegistry是一个符合监管标准的基于云的中央存储库，用于多中心心血管研究的真实世界临床数据和DICOM图像。包括基于结果的数据。该注册表包含299,622,066个DICOM图像和456,678个患者年随访。来自美国20个地点的154,458次CMR扫描的数据显示，2015年后，心肌病是最常见的适应症，大环钆造影剂利用率为89%。总死亡率为8%，LVEF<35%的患者发病率较高，异常壁运动,缺血存在，或梗塞部位。登记处旨在通过合作努力促进基于证据的CMR利用，以积极影响心血管结果。
