Abstract：
Cancer cells undergo metabolic reprogramming to survive in hypoxic conditions and meet the elevated energy demands of the cancer microenvironment. This metabolic alteration is orchestrated by hypoxia-inducible factor 1 (HIF-1), regulating various processes within cancer cells. The intricate metabolic modifications induced by hypoxia underscore the significance of HIF-1-induced metabolic reprogramming in promoting each aspect of cancer progression. The complex interactions between HIF-1 signalling and cellular metabolic processes in response to hypoxia are examined in this study, focusing on the metabolism of carbohydrates, nucleotides, lipids, and amino acids. Comprehending the various regulatory mechanisms controlled by HIF-1 in cellular metabolism sheds light on the intricate biology of cancer growth and offers useful insights for developing targeted treatments.
摘要：
癌细胞经历代谢重编程以在低氧条件下存活并满足癌症微环境的升高的能量需求。这种代谢改变是由缺氧诱导因子1（HIF-1），调节癌细胞内的各种过程。缺氧诱导的复杂代谢修饰强调了HIF-1诱导的代谢重编程在促进癌症进展的各个方面的重要性。HIF-1信号和细胞代谢过程之间的复杂的相互作用响应缺氧在这项研究中进行了检查，专注于碳水化合物的代谢，核苷酸,脂质，和氨基酸。理解细胞代谢中HIF-1控制的各种调节机制揭示了癌症生长的复杂生物学，并为开发靶向治疗提供了有用的见解。
