Abstract：
The white-tufted marmoset is a small, nonhuman primate that is rapidly gaining popularity as a model organism, especially for neuroscience research. To date, little work in the alcohol research field has utilized the marmoset. As a step toward establishing the marmoset as a research model for alcohol experimentation, a series of exploratory studies were undertaken to characterize ethanol drinking behavior. A voluntary drinking paradigm was established whereby the common marmoset would consume pharmacologically relevant amounts of ethanol. To facilitate ethanol consumption, ethanol was mixed with a marshmallow flavored solution (hereafter called marshmallow juice) to mask the presumed adverse taste of ethanol. Using marshmallow juice flavored solutions, marmosets readily consumed ethanol up to 1 g/kg during 10 min binge-like drinking sessions or up to 5 g/kg during ∼4 h drinking sessions. Consumption of 1.0-1.5 g/kg during a 30 min session resulted in blood ethanol concentrations of 49-73 mg/dl, which are predicted to be pharmacologically relevant. In animals that were stably consuming ethanol in marshmallow juice, gradually reducing the concentration of the marshmallow juice flavoring resulted in markedly reduced ethanol consumption. Lastly, when offered a choice between ethanol in marshmallow juice and marshmallow juice alone, marmosets displayed a very strong preference for the marshmallow juice solution without ethanol. From these studies, it is concluded that marmosets will voluntarily consume ethanol if the taste is masked with a sweet solution such as marshmallow juice. These studies represent the first report of alcohol consumption and preference in the white-tufted marmoset.
摘要：
白色簇绒猴是一个小的，作为模型生物正在迅速普及的非人类灵长类动物，尤其是神经科学研究.迄今为止,在酒精研究领域的工作很少，已经利用了the猴。作为朝着将the猴作为酒精实验的研究模型迈出的一步，进行了一系列探索性研究来表征乙醇饮用行为。建立了自愿饮酒范式，普通的the猴将消耗与药理学相关的乙醇量。为了促进乙醇消费，将乙醇与棉花糖调味溶液(以下称为棉花糖汁)混合以掩盖假定的乙醇的不良味道。使用棉花糖汁调味溶液，Marmosets在10分钟的暴饮暴食式饮酒过程中容易消耗高达1g/kg的乙醇，或在〜4小时饮酒过程中消耗高达5g/kg的乙醇。在30分钟内消耗1.0-1.5g/kg导致血液乙醇浓度为49-73mg/dl，预测是药理学相关的。在稳定消耗棉花糖汁中乙醇的动物中，逐渐降低棉花糖汁调味剂的浓度导致乙醇消耗显着减少。最后,当提供棉花糖汁中的乙醇和单独的棉花糖汁之间的选择时，marmosets对不含乙醇的棉花糖汁溶液表现出非常强烈的偏好。从这些研究中,结论是，如果用棉花糖汁之类的甜味溶液掩盖了味道，猕猴将自愿食用乙醇。这些研究代表了白色簇绒猴饮酒和偏爱的第一份报告。
