Abstract：
The neonatal Fc receptor (FcRn) can transport IgG and antigen-antibody complexes participating in mucosal immune responses that protect the host from most pathogens\' invasion via the respiratory, digestive, and urogenital tracts. FcRn expression can be triggered upon stimulation with pathogenic invasion on mucosal surfaces, which may significantly modulate the innate immune response of the host. As an immunoglobulin transport receptor, FcRn is implicated in the pathophysiology of immune-related diseases such as infection and autoimmune disorders. In this review, we thoroughly summarize the recent advancement of FcRn in mucosal immunity and its therapeutic strategy. This includes insights into its regulation mechanisms of FcRn expression influenced by pathogens, its emerging role in mucosal immunity and its potential probability as a therapeutic target in infection and autoimmune diseases.
摘要：
新生儿Fc受体（FcRn）可以转运IgG和抗原-抗体复合物，参与粘膜免疫反应，保护宿主免受大多数病原体通过呼吸道侵入，消化性,和泌尿生殖道.FcRn表达可以在粘膜表面的病原侵入刺激时触发，这可能显著调节宿主的先天免疫应答。作为免疫球蛋白转运受体,FcRn与免疫相关疾病如感染和自身免疫性疾病的病理生理学有关。在这次审查中,我们全面总结了FcRn在黏膜免疫方面的最新进展及其治疗策略。这包括对其受病原体影响的FcRn表达调控机制的见解，它在粘膜免疫中的新兴作用及其作为感染和自身免疫性疾病治疗靶点的潜在可能性。
