Abstract：
Orthoflaviviruses are enveloped positive-sense RNA viruses comprising numerous human pathogens transmitted by hematophagous arthropods. This includes viruses such as dengue virus, Zika virus, and yellow fever virus. The viral nonstructural protein NS1 plays a central role in the pathogenesis and cycle of these viruses by acting in two different forms: associated with the plasma membrane (NS1m) or secreted outside the cell (NS1s). The versatility of NS1 is evident in its ability to modulate various aspects of the infectious process, from immune evasion to pathogenesis. As an intracellular protein, it disrupts many processes, interfering with signaling pathways and facilitating viral replication in concert with other viral proteins. As a secreted protein, NS1 actively participates in immune evasion, interfering with the host immune system, inhibiting the complement system, facilitating viral dissemination, and disrupting the integrity of endothelial barriers. This review primarily aims to address the role of NS1 in viral pathogenesis associated with orthoflaviviruses.
摘要：
正黄病毒是有包膜的正义RNA病毒,其包含由食血节肢动物传播的许多人病原体。这包括登革热病毒等病毒，寨卡病毒,黄热病病毒。病毒非结构蛋白NS1通过以两种不同形式起作用在这些病毒的发病机理和循环中起重要作用:与质膜(NS1m)相关或在细胞外分泌(NS1s)。NS1的多功能性在其调节感染过程各个方面的能力方面很明显，从免疫逃避到发病机制。作为一种细胞内蛋白质，它扰乱了许多进程，干扰信号通路并促进与其他病毒蛋白一致的病毒复制。作为一种分泌蛋白,NS1积极参与免疫逃避，干扰宿主免疫系统，抑制补体系统，促进病毒传播，破坏内皮屏障的完整性。这篇综述主要旨在探讨NS1在与正黄病毒相关的病毒发病机理中的作用。
